Cyclic phosphodiesterase activity and the action of papaverine

Papaverine, a smooth muscle relaxant, inhibits phosphodiesterase activity in homogenates of rabbit aorta, rat uterus and rat diaphragm.This inhibitory effect of papaverine is about 15–30 times greater than that of theophylline. In rat diaphragm, papaverine increased glycogenolysis to the same extent...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 40; no. 1; pp. 64 - 69
Main Authors Triner, L., Vulliemoz, Y., Schwartz, I., Nahas, G.G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.07.1970
Subjects
Animals
Aorta - enzymology
Cyclic AMP - physiology
Diaphragm - drug effects
Diaphragm - enzymology
Drug Synergism
Epinephrine - pharmacology
Female
Glycogen - metabolism
Kinetics
Male
Muscle, Smooth - enzymology
Muscles - physiology
Papaverine - pharmacology
Phosphoric Monoester Hydrolases - antagonists & inhibitors
Rats
Theophylline
Uterus - enzymology
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Summary:Papaverine, a smooth muscle relaxant, inhibits phosphodiesterase activity in homogenates of rabbit aorta, rat uterus and rat diaphragm.This inhibitory effect of papaverine is about 15–30 times greater than that of theophylline. In rat diaphragm, papaverine increased glycogenolysis to the same extent as epinephrine and had a synergistic effect with epinephrine on glycogen breakdown. These results suggest that the relaxing effect of papaverine might be due to its action on phosphodiesterase and are in agreement with the postulation that cyclic 3′, 5′-AMP participates in the control of smooth muscle tone and contractility.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(70)91046-6