Cyclic phosphodiesterase activity and the action of papaverine
Papaverine, a smooth muscle relaxant, inhibits phosphodiesterase activity in homogenates of rabbit aorta, rat uterus and rat diaphragm.This inhibitory effect of papaverine is about 15–30 times greater than that of theophylline. In rat diaphragm, papaverine increased glycogenolysis to the same extent...
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Published in | Biochemical and biophysical research communications Vol. 40; no. 1; pp. 64 - 69 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
13.07.1970
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Subjects | |
Online Access | Get full text |
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Summary: | Papaverine, a smooth muscle relaxant, inhibits phosphodiesterase activity in homogenates of rabbit aorta, rat uterus and rat diaphragm.This inhibitory effect of papaverine is about 15–30 times greater than that of theophylline. In rat diaphragm, papaverine increased glycogenolysis to the same extent as epinephrine and had a synergistic effect with epinephrine on glycogen breakdown. These results suggest that the relaxing effect of papaverine might be due to its action on phosphodiesterase and are in agreement with the postulation that cyclic 3′, 5′-AMP participates in the control of smooth muscle tone and contractility. |
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ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/0006-291X(70)91046-6 |