Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population

• Published in: Environment international Vol. 186; p. 108565
• Main Authors: Khoury, Nadine, Ángeles Martínez, María, Nishi, Stephanie K., Ángel Martínez-González, Miguel, Corella, Dolores, Castañer, Olga, Alfredo Martínez, J., Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Manuel Santos-Lozano, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Cinza Sanjurjo, Sergio, Pintó, Xavier, Juan Gaforio, José, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, V Sorli, Jose, Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Ortiz-Díaz, Francisco, Gómez-Gracia, Enrique, Zulet, MA, Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vazquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, Salas-Salvadó, Jordi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2024; Elsevier
• Subjects: Aged; Aged, 80 and over; Alkanesulfonic Acids - blood; Blood Glucose - analysis; Body Mass Index; Diabetes; Diabetes Mellitus, Type 2; Diet - statistics & numerical data; Dietary intake; Endocrine Disruptors; Endocrine disruptors (EDs); Environmental Pollutants - blood; Female; Fluorocarbons - blood; Glucose homeostasis parameters; Homeostasis; Humans; Male; Middle Aged; Perfluorooctane sulfonate (PFOS); Prospective Studies; LOD; er-MedDiet; FFQs; TWI; Dietary intake; Glucose homeostasis parameters; PFAS; UB; EFSA; CVD; HOMA-IR; SD; Endocrine disruptors (EDs); Eds; LB; Diabetes; Perfluorooctane sulfonate (PFOS); HbA1c; BMI; PFOS
• ISSN: 0160-4120; 1873-6750
• DOI: 10.1016/j.envint.2024.108565

•Eggs, fish and seafood, and fruits and vegetables contributed the most to the PFOS dietary intake.•Dietary intake of PFOS was associated with fasting plasma glucose and HbA1c at baseline.•Dietary intake of PFOS was associated with an increase in HOMA-IR and BMI after 1-year of follow-up. Endocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. To assess at baseline and after 1-year of follow-up associations between estimated dietary intake (DI) of PFOS, and glucose homeostasis parameters and body-mass-index (BMI) in a senior population of 4600 non-diabetic participants from the PREDIMED-plus study. Multivariable linear regression models were conducted to assess associations between baseline PFOS-DI at lower bound (LB) and upper bound (UB) established by the EFSA, glucose homeostasis parameters and BMI. Compared to those in the lowest tertile, participants in the highest tertile of baseline PFOS-DI in LB and UB showed higher levels of HbA1c [β-coefficient(CI)] [0.01 %(0.002 to 0.026), and [0.06 mg/dL(0.026 to 0.087), both p-trend ≤ 0.001], and fasting plasma glucose in the LB PFOS-DI [1.05 mg/dL(0.050 to 2.046),p-trend = 0.022]. Prospectively, a positive association between LB of PFOS-DI and BMI [0.06 kg/m2(0.014 to 0.106) per 1-SD increment of energy-adjusted PFOS-DI was shown. Participants in the top tertile showed an increase in HOMA-IR [0.06(0.016 to 0.097), p-trend = 0.005] compared to participants in the reference tertile after 1-year of follow-up. This is the first study to explore the association between DI of PFOS and glucose homeostasis. In this study, a high baseline DI of PFOS was associated with a higher levels of fasting plasma glucose and HbA1c and with an increase in HOMA-IR and BMI after 1-year of follow-up.