Is the Use of Cardioactive Steroids Appropriate in Managing Aluminium Phosphide Poisoning-Induced Heart Failure?

Following the publication of a review on aluminium phosphide poisoning in your journal, as well as another letter to the editor regarding this subject, we would like to add to this discussion (1,2). Patients with acute aluminium phosphide poisoning generally suffer from multiple organ dysfunction du...

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Published inArhiv za higijenu rada i toksikologiju Vol. 64; no. 3; pp. 477 - 478
Main Authors Marashi, Sayed Mahdi, Majidi, Mohammad, Sadeghian, Mehran, Ahmadi, Shapour, Raji Asadabadi, Hojatollah, Nasri Nasrabadi, Zeynab
Format Journal Article
LanguageEnglish
Published Croatia Institute for Medical Research and Occupational Health 01.09.2013
Subjects
Aluminum Compounds - poisoning
Humans
Pesticides - poisoning
Phosphines - poisoning
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Summary:Following the publication of a review on aluminium phosphide poisoning in your journal, as well as another letter to the editor regarding this subject, we would like to add to this discussion (1,2). Patients with acute aluminium phosphide poisoning generally suffer from multiple organ dysfunction due to diminished mitochondrial activity and oxidative phophorylation. This is the result of the direct effect of toxins on mitochondrial performance (3,4). As Shadnia et al. (5) stated, this toxicity may, among other consequences, lead to congestive heart failure. Cardioactive steroids were until recently considered as a supposition that improves cardiac functioning and were used in the treatment of heart failure (6).
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ISSN:0004-1254
1848-6312
1848-6312
DOI:10.2478/10004-1254-64-2013-2439