Comparison of the effects on lipoproteins and apolipoproteins of a diet high in monounsaturated fatty acids, enriched with avocado, and a high-carbohydrate diet

• Published in: The American journal of clinical nutrition Vol. 56; no. 4; pp. 671 - 677
• Main Authors: Colquhoun, DM, Moores, D, Somerset, SM, Humphries, JA
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.10.1992; American Society for Clinical Nutrition
• Subjects: ACIDE GRAS; ACIDOS GRASOS; Adult; AGUACATE; Apolipoproteins; Apolipoproteins - metabolism; Apolipoproteins B - metabolism; AVOCADOS; AVOCAT; Biological and medical sciences; BLOOD LIPIDS; BLOOD SERUM; CARBOHIDRATOS; CARBOHYDRATES; CHOLESTEROL; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; COLESTEROL; CORPS GRAS; DIET; DIETA; Dietary Carbohydrates - administration & dosage; Dietary Fats - administration & dosage; Disorders of blood lipids. Hyperlipoproteinemia; EXPERIMENTATION; EXPERIMENTOS; EXPERIMENTS; FATS; FATTY ACIDS; Fatty Acids, Monounsaturated - administration & dosage; Female; FEMME; Fruit; GLUCIDE; GRASAS; HIGH DENSITY LIPOPROTEIN; Humans; LIPAEMIA; LIPEMIA; LIPEMIE; lipids; LIPOPROTEINAS; LIPOPROTEINE; LIPOPROTEINS; Lipoproteins - blood; LOW DENSITY LIPOPROTEIN; Medical sciences; Metabolic diseases; Middle Aged; MONOENOIC FATTY ACIDS; monounsaturated fatty acids; MUJERES; QUEENSLAND; REGIME ALIMENTAIRE; SERUM SANGUIN; SUERO SANGUINEO; TRIACYLGLYCEROLS; TRIGLICERIDOS; TRIGLYCERIDE; TRIGLYCERIDES; WOMEN; cholesterol; lipids; Apolipoproteins; monounsaturated fatty acids; lipoproteins; Human; Hypercholesterolemia; Diet therapy; Diet; Avocado; Metabolic diseases; Unsaturated fatty acid; Lipids; Lipoprotein; Cholesterol
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/56.4.671

A randomized trial was conducted to compare effects of a diet high in monounsaturated fatty acids, enriched with avocado (AE), and a high-complex-carbohydrate diet (AHA-III) on blood lipid concentrations. Fifteen females between 37 and 58 y of age were allocated either to AE followed by AHA-III, or vice versa. Each dietary phase lasted 3 wk. Both diets were found to lower total cholesterol compared with baseline values. AE was more effective, with an 8.2% decrease (P < 0.05) whereas AHA-III was associated with a 4.9% decrease (NS). Lowdensity-lipoprotein cholesterol and apolipoprotein B decreased significantly on AE but not on AHA-III (P < 0.05). The highdensity-lipoprotein (HDL) concentration did not change on AE but decreased 13.9% on AHA-III (P < 0.01). It is concluded that AE is more effective than is AHA-III in decreasing total cholesterol, and, unlike AHA-III, it does not decrease HDL concentrations.