Evaluation of serum vitamin D and IgE in patients with bronchial asthma

• Published in: Egyptian Journal of Bronchology Vol. 10; no. 2; pp. 113 - 116
• Main Authors: El Gazzar, Ahmed G., Essawy, Tarek S., Awaad, Ahmed H., Mansour, Amira I.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2016; Wolters Kluwer - Medknow Publications; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Alfacalcidol; Analysis; Asthma; bronchial asthma; Calcifediol; Care and treatment; Diagnosis; Enzyme-linked immunosorbent assay; Health aspects; Immunoglobulin E; Medicine & Public Health; Original Article; Risk factors; Vitamin D; Vitamin deficiency; Egypt; immunoglobulin E; bronchial asthma; vitamin D
• ISSN: 1687-8426; 2314-8551
• DOI: 10.4103/1687-8426.184365

Background Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. Aim This study was carried out to evaluate the level of vitamin D and immunoglobulin E (IgE) in asthmatic patients during exacerbation and after remission. Patients and methods This study was carried out on 30 patients with bronchial asthma diagnosed and classified according to Global Initiative for Asthma 2015 and 20 healthy individuals. Serum vitamin D and IgE were measured using enzyme-linked immunosorbent assay for all participants. Results Vitamin D level was highly significantly lower in the asthmatic group during exacerbation compared with the asthmatic group after remission and the control group, and the total IgE level was highly significantly higher in the asthmatic groups compared with the control group. Conclusion Asthmatic patients might have an increased risk of having vitamin D deficiency during exacerbation and after remission, whereas the levels of serum total IgE level was high in asthmatic patients compared with normal individuals.