Reversible Bioadhesives Using Tannic Acid Primed Thermally‐Responsive Polymers

A two‐layer approach is reported for the formation of a thermally triggered reversible adhesive, involving a thermally‐responsive polymer matrix coated on tannic acid‐pretreated substrates/tissues. Interfacial adhesion originates from strong molecular interactions of tannic acid with both the polyme...

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Bibliographic Details
Published inAdvanced functional materials Vol. 30; no. 5
Main Authors Li, Bin, Whalen, John J., Humayun, Mark S., Thompson, Mark E.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc 01.01.2020
Subjects
Adhesive strength
Adhesives
Cohesion
cohesive failure
Gelation
hydrogels
Industrial applications
Materials science
Modular design
Molecular interactions
Phase transitions
Polymers
responsive polymers
reversible adhesives
Sol-gel processes
Substrates
Tannic acid
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Summary:A two‐layer approach is reported for the formation of a thermally triggered reversible adhesive, involving a thermally‐responsive polymer matrix coated on tannic acid‐pretreated substrates/tissues. Interfacial adhesion originates from strong molecular interactions of tannic acid with both the polymer matrix and the substrate/tissue. The reversibility is due to a temperature‐triggered phase transition of the polymer matrix, leading to cohesive failure. Depending on different gelation mechanisms, the polymer forms a highly cohesive gel or soft solid upon either warming or cooling, leading to a strong adhesion to the tissues at physiological temperatures. Detachment of the adhesive is triggered by a temperature‐induced compromise of cohesive strength of the polymer matrix, by the opposite gel‐to‐sol transition. This facile, low‐cost, and modular design offers a reversible adhesive platform which is useful for biomedical and industrial applications. A two‐layer approach is reported for the formation of a thermally‐triggered reversible adhesive, involving a thermally‐responsive polymer matrix coated on tannic acid–pretreated substrate/tissue. The reversibility is due to a phase transition of the polymer matrix, leading to cohesive failure. The “bound state” of the adhesive gives strong and durable adhesion to the tissue at physiological temperatures of 22–37 °C.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201907478