Self‐Propelled, High‐Crystalline Hydrogen‐Bonded Enzymatic Framework Assembled by Bottom‐Up Strategy

• Published in: Small structures Vol. 4; no. 7
• Main Authors: Yang, Huangsheng, Fu, Jiahui, Huang, Wei, Wu, Tong, Huang, Siming, Chen, Guosheng, Ouyang, Gangfeng
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 01.07.2023; Wiley-VCH
• Subjects: Adsorption; biomimetic engineering; Biomimetics; Catalase; Composite materials; Crystallization; Efficiency; enzyme immobilization; Enzymes; Exoskeletons; Fourier transforms; Hydrogen; hydrogen-bonded organic frameworks; pollutant removal; Proteins; self-propelling motion; Sorbents
• ISSN: 2688-4062; 2688-4062
• DOI: 10.1002/sstr.202200346

Biomimetic engineering presents an insightful strategy to access fascinating biocomposites integrating biological, chemical, and material functions. Herein, a new self‐propelled hydrogen‐bonded enzymatic framework through a biomimetic bottom‐up strategy is reported. The metal‐free, mesoporous, and photoactive hydrogen‐bonded organic framework (HOF) exoskeleton is in situ grown around catalase (CAT), an enzyme well known for its ability for the biocatalytic O2 generation. This HOF biomimetic method affords the ultrahigh encapsulation efficiency of CAT, yet well preserves the high crystallinity and periodically arranged mesochannels of HOF. The resultant hydrogen‐bonded enzymatic framework enables the self‐propelled motion with the help of a biocatalytic O2 bubble. Given the exquisite architecture, the HOF shell can serve as the dynamical sorbent for pollutant removal. More than that, it is showcased that the intrinsic photoactivity of HOF can be improved by the self‐propelled motion. This study reports a new self‐propelled hydrogen‐bonded enzymatic framework through a biomimetic bottom‐up strategy. The formed bio‐nanoarchitecture is chemically stable and exhibits high biocatalytic efficiency for O2 bubble generation, enabling the superior self‐propulsion rate under a low “fuel” concentration. In addition, the potential applications for pollutant removal and photocatalysis are well disclosed.