MR‐Based Electrical Conductivity Imaging of Liver Fibrosis in an Experimental Rat Model
Background Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracell...
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Published in | Journal of magnetic resonance imaging Vol. 53; no. 2; pp. 554 - 563 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
01.02.2021
Wiley Subscription Services, Inc |
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Abstract | Background
Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracellular space.
Purpose
To evaluate the feasibility of an MR‐based electrical conductivity imaging that can detect the changes in a tissue condition associated with the progression of liver fibrosis.
Study Type
Prospective phantom and animal study.
Animal Model
Fibrosis was induced by weekly intraperitoneal injection of dimethylnitrosamine (DMN) in 45 male Sprague–Dawley rats.
Field Strength/Sequence
3T MRI with a multispin‐echo pulse sequence.
Assessment
The percentage change of conductivity (Δσ, %) in the same region‐of‐interest (ROI) was calculated from the DMN‐treated rats based on the values of the normal control rats. The percentage change was also calculated between the ROIs in each DMN‐treated group.
Statistical Tests
One‐way analysis of variance (ANOVA) and a two‐sample t‐test were performed.
Results
Liver tissues in normal control rats showed a uniform conductivity distribution of 56.6 ± 4.4 (mS/m). In rats more than 5 weeks after induction, the fibrous region showed an increased conductivity of ≥12% compared to that of the corresponding normal control rats. From regional comparisons in the same liver, the fibrous region showed an increased conductivity of ≥11% compared to the opposite, less induced region of rats more than 5 weeks after induction. Liver samples from the fibrous region represent tissue damages such as diffuse centrilobular congestion with marked dilatation of central veins from the histological findings. Immunohistochemistry revealed significant levels of attenuated fibrosis and increased inflammatory response.
Data Conclusion
The increased conductivity in the fibrous region is related to the changes of the extracellular space. The correlation between the collagen deposition and conductivity changes is essential for future clinical studies.
Level of Evidence 2
Technical Efficacy Stage 2
J. MAGN. RESON. IMAGING 2021;53:554–563. |
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AbstractList | Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracellular space.
To evaluate the feasibility of an MR-based electrical conductivity imaging that can detect the changes in a tissue condition associated with the progression of liver fibrosis.
Prospective phantom and animal study.
Fibrosis was induced by weekly intraperitoneal injection of dimethylnitrosamine (DMN) in 45 male Sprague-Dawley rats.
3T MRI with a multispin-echo pulse sequence.
The percentage change of conductivity (Δσ, %) in the same region-of-interest (ROI) was calculated from the DMN-treated rats based on the values of the normal control rats. The percentage change was also calculated between the ROIs in each DMN-treated group.
One-way analysis of variance (ANOVA) and a two-sample t-test were performed.
Liver tissues in normal control rats showed a uniform conductivity distribution of 56.6 ± 4.4 (mS/m). In rats more than 5 weeks after induction, the fibrous region showed an increased conductivity of ≥12% compared to that of the corresponding normal control rats. From regional comparisons in the same liver, the fibrous region showed an increased conductivity of ≥11% compared to the opposite, less induced region of rats more than 5 weeks after induction. Liver samples from the fibrous region represent tissue damages such as diffuse centrilobular congestion with marked dilatation of central veins from the histological findings. Immunohistochemistry revealed significant levels of attenuated fibrosis and increased inflammatory response.
The increased conductivity in the fibrous region is related to the changes of the extracellular space. The correlation between the collagen deposition and conductivity changes is essential for future clinical studies. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:554-563. BackgroundLiver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracellular space.PurposeTo evaluate the feasibility of an MR‐based electrical conductivity imaging that can detect the changes in a tissue condition associated with the progression of liver fibrosis.Study TypeProspective phantom and animal study.Animal ModelFibrosis was induced by weekly intraperitoneal injection of dimethylnitrosamine (DMN) in 45 male Sprague–Dawley rats.Field Strength/Sequence3T MRI with a multispin‐echo pulse sequence.AssessmentThe percentage change of conductivity (Δσ, %) in the same region‐of‐interest (ROI) was calculated from the DMN‐treated rats based on the values of the normal control rats. The percentage change was also calculated between the ROIs in each DMN‐treated group.Statistical TestsOne‐way analysis of variance (ANOVA) and a two‐sample t‐test were performed.ResultsLiver tissues in normal control rats showed a uniform conductivity distribution of 56.6 ± 4.4 (mS/m). In rats more than 5 weeks after induction, the fibrous region showed an increased conductivity of ≥12% compared to that of the corresponding normal control rats. From regional comparisons in the same liver, the fibrous region showed an increased conductivity of ≥11% compared to the opposite, less induced region of rats more than 5 weeks after induction. Liver samples from the fibrous region represent tissue damages such as diffuse centrilobular congestion with marked dilatation of central veins from the histological findings. Immunohistochemistry revealed significant levels of attenuated fibrosis and increased inflammatory response.Data ConclusionThe increased conductivity in the fibrous region is related to the changes of the extracellular space. The correlation between the collagen deposition and conductivity changes is essential for future clinical studies.Level of Evidence 2Technical Efficacy Stage 2J. MAGN. RESON. IMAGING 2021;53:554–563. Background Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracellular space. Purpose To evaluate the feasibility of an MR‐based electrical conductivity imaging that can detect the changes in a tissue condition associated with the progression of liver fibrosis. Study Type Prospective phantom and animal study. Animal Model Fibrosis was induced by weekly intraperitoneal injection of dimethylnitrosamine (DMN) in 45 male Sprague–Dawley rats. Field Strength/Sequence 3T MRI with a multispin‐echo pulse sequence. Assessment The percentage change of conductivity (Δ σ , %) in the same region‐of‐interest (ROI) was calculated from the DMN‐treated rats based on the values of the normal control rats. The percentage change was also calculated between the ROIs in each DMN‐treated group. Statistical Tests One‐way analysis of variance (ANOVA) and a two‐sample t ‐test were performed. Results Liver tissues in normal control rats showed a uniform conductivity distribution of 56.6 ± 4.4 (mS/m). In rats more than 5 weeks after induction, the fibrous region showed an increased conductivity of ≥12% compared to that of the corresponding normal control rats. From regional comparisons in the same liver, the fibrous region showed an increased conductivity of ≥11% compared to the opposite, less induced region of rats more than 5 weeks after induction. Liver samples from the fibrous region represent tissue damages such as diffuse centrilobular congestion with marked dilatation of central veins from the histological findings. Immunohistochemistry revealed significant levels of attenuated fibrosis and increased inflammatory response. Data Conclusion The increased conductivity in the fibrous region is related to the changes of the extracellular space. The correlation between the collagen deposition and conductivity changes is essential for future clinical studies. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:554–563. Background Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracellular space. Purpose To evaluate the feasibility of an MR‐based electrical conductivity imaging that can detect the changes in a tissue condition associated with the progression of liver fibrosis. Study Type Prospective phantom and animal study. Animal Model Fibrosis was induced by weekly intraperitoneal injection of dimethylnitrosamine (DMN) in 45 male Sprague–Dawley rats. Field Strength/Sequence 3T MRI with a multispin‐echo pulse sequence. Assessment The percentage change of conductivity (Δσ, %) in the same region‐of‐interest (ROI) was calculated from the DMN‐treated rats based on the values of the normal control rats. The percentage change was also calculated between the ROIs in each DMN‐treated group. Statistical Tests One‐way analysis of variance (ANOVA) and a two‐sample t‐test were performed. Results Liver tissues in normal control rats showed a uniform conductivity distribution of 56.6 ± 4.4 (mS/m). In rats more than 5 weeks after induction, the fibrous region showed an increased conductivity of ≥12% compared to that of the corresponding normal control rats. From regional comparisons in the same liver, the fibrous region showed an increased conductivity of ≥11% compared to the opposite, less induced region of rats more than 5 weeks after induction. Liver samples from the fibrous region represent tissue damages such as diffuse centrilobular congestion with marked dilatation of central veins from the histological findings. Immunohistochemistry revealed significant levels of attenuated fibrosis and increased inflammatory response. Data Conclusion The increased conductivity in the fibrous region is related to the changes of the extracellular space. The correlation between the collagen deposition and conductivity changes is essential for future clinical studies. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:554–563. BACKGROUNDLiver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracellular space. PURPOSETo evaluate the feasibility of an MR-based electrical conductivity imaging that can detect the changes in a tissue condition associated with the progression of liver fibrosis. STUDY TYPEProspective phantom and animal study. ANIMAL MODELFibrosis was induced by weekly intraperitoneal injection of dimethylnitrosamine (DMN) in 45 male Sprague-Dawley rats. FIELD STRENGTH/SEQUENCE3T MRI with a multispin-echo pulse sequence. ASSESSMENTThe percentage change of conductivity (Δσ, %) in the same region-of-interest (ROI) was calculated from the DMN-treated rats based on the values of the normal control rats. The percentage change was also calculated between the ROIs in each DMN-treated group. STATISTICAL TESTSOne-way analysis of variance (ANOVA) and a two-sample t-test were performed. RESULTSLiver tissues in normal control rats showed a uniform conductivity distribution of 56.6 ± 4.4 (mS/m). In rats more than 5 weeks after induction, the fibrous region showed an increased conductivity of ≥12% compared to that of the corresponding normal control rats. From regional comparisons in the same liver, the fibrous region showed an increased conductivity of ≥11% compared to the opposite, less induced region of rats more than 5 weeks after induction. Liver samples from the fibrous region represent tissue damages such as diffuse centrilobular congestion with marked dilatation of central veins from the histological findings. Immunohistochemistry revealed significant levels of attenuated fibrosis and increased inflammatory response. DATA CONCLUSIONThe increased conductivity in the fibrous region is related to the changes of the extracellular space. The correlation between the collagen deposition and conductivity changes is essential for future clinical studies. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:554-563. |
Author | Katoch, Nitish Park, Ji Ae Choi, Bup Kyung Kim, Hyung Joong Hur, Young Hoe Woo, Eung Je Kim, Jin Woong Kim, Hyun Bum |
Author_xml | – sequence: 1 givenname: Jin Woong surname: Kim fullname: Kim, Jin Woong organization: Chosun University Hospital and Chosun University College of Medicine – sequence: 2 givenname: Hyun Bum surname: Kim fullname: Kim, Hyun Bum organization: Kyung Hee University – sequence: 3 givenname: Young Hoe surname: Hur fullname: Hur, Young Hoe organization: Chonnam National University Hwasun Hospital and Chonnam National University Medical School – sequence: 4 givenname: Bup Kyung surname: Choi fullname: Choi, Bup Kyung organization: Kyung Hee University – sequence: 5 givenname: Nitish surname: Katoch fullname: Katoch, Nitish organization: Kyung Hee University – sequence: 6 givenname: Ji Ae surname: Park fullname: Park, Ji Ae organization: Korea Institute of Radiological & Medical Science – sequence: 7 givenname: Hyung Joong orcidid: 0000-0001-7591-9079 surname: Kim fullname: Kim, Hyung Joong email: bmekim@khu.ac.kr organization: Kyung Hee University – sequence: 8 givenname: Eung Je surname: Woo fullname: Woo, Eung Je organization: Kyung Hee University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32614131$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1002_jmri_27701 crossref_primary_10_1371_journal_pone_0287614 crossref_primary_10_3389_fmed_2023_1160053 crossref_primary_10_1007_s12028_023_01776_4 crossref_primary_10_3390_app13137950 |
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Keywords | ion mobility liver fibrosis magnetic resonance imaging electrical conductivity ion concentration |
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Notes | Jin Woong Kim and Hyun Bum Kim contributed equally to this work. Contract grant sponsor: National Research Foundation of Korea (NRF) grants funded by the Korean government; Contract grant numbers: 2018R1D1A1B07046619, 2019R1A2C2088573, 2020R1I1A3065215, and 2020R1A2C200790611. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can... Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide... BackgroundLiver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can... BACKGROUNDLiver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can... |
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SubjectTerms | Animal models Animals Collagen Dimethylnitrosamine Electric Conductivity Electrical conductivity Electrical resistivity Extracellular matrix Fibrosis Field strength Immunohistochemistry Inflammation Inflammatory response ion concentration ion mobility Liver Liver - diagnostic imaging Liver - pathology Liver Cirrhosis - chemically induced Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - pathology liver fibrosis Magnetic resonance imaging Male Prospective Studies Rats Rats, Sprague-Dawley Rodents Statistical analysis Statistical methods Statistical tests Tissues Variance analysis |
Title | MR‐Based Electrical Conductivity Imaging of Liver Fibrosis in an Experimental Rat Model |
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