Evaluation of bilateral cingulum with tractography in patients with Alzheimer's disease

A fiber-tracking algorithm was used to extract fractional anisotropy of bilateral cingulum bundles in patients with probable Alzheimer's disease and normal aging controls. In addition, their hippocampal volumes were measured manually. Relative to normal controls, Alzheimer's disease patien...

Full description

Saved in:
Bibliographic Details
Published inNeuroreport Vol. 16; no. 12; p. 1275
Main Authors Xie, Sheng, Xiao, Jiang Xi, Wang, Yin Hua, Wu, Hong Kun, Gong, Gao Lang, Jiang, Xue Xiang
Format Journal Article
LanguageEnglish
Published England 22.08.2005
Subjects
Aged
Aged, 80 and over
Algorithms
Alzheimer Disease - pathology
Anisotropy
Atrophy - pathology
Female
Functional Laterality
Gyrus Cinguli - pathology
Hippocampus - pathology
Humans
Magnetic Resonance Imaging - methods
Male
Mental Status Schedule
Middle Aged
Statistics as Topic
Online AccessGet more information

Cover

More Information
Summary:A fiber-tracking algorithm was used to extract fractional anisotropy of bilateral cingulum bundles in patients with probable Alzheimer's disease and normal aging controls. In addition, their hippocampal volumes were measured manually. Relative to normal controls, Alzheimer's disease patients showed a significant reduction of fractional anisotropy and hippocampal volumes. Significant correlation was observed between fractional anisotropy values and volumes of hippocampi and mini-mental state examination scores. This study suggests that lower anisotropy of cingulum bundles is associated with cognitive dysfunction and atrophy of the limbic system.
ISSN:0959-4965
1473-558X
DOI:10.1097/01.wnr.0000174061.41897.ee