The role of the long non‐coding RNA HOXA11‐AS in promoting proliferation and metastasis of malignant tumors

• Published in: Cell biology international Vol. 42; no. 12; pp. 1596 - 1601
• Main Authors: Lu, Shounan, Jiang, Xingming, Su, Zhilei, Cui, Zhankun, Fu, Wen, Tai, Sheng
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2018
• Subjects: Animals; Antisense RNA; Brain tumors; cancer; carcinogenesis; Cell Proliferation - genetics; Gastric cancer; Glioma; HOXA11‐AS; Humans; LncRNA; Metastases; Metastasis; miRNA; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Neoplasms - genetics; Neoplasms - pathology; Ovarian cancer; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Therapeutic applications; Tumor markers; Tumors; LncRNA; cancer; HOXA11-AS; carcinogenesis
• ISSN: 1065-6995; 1095-8355
• DOI: 10.1002/cbin.11045

Long non‐coding RNA (lncRNA) is one of the focuses and hotspots of biological research in recent years. At the same time, tumors have become the main disease that endangers human health. In recent years, a large number of researchers have explored the relationship between lncRNA and tumors. HOXA11‐AS is one of these lncRNAs. The long non‐coding RNA HOXA11 antisense RNA (HOXA11‐AS) is a novel lncRNA recently discovered. It is found in a variety of tumors such as ovarian cancer, glioma, and gastric cancer (GC) and so on, and is defined as an oncogene. It promotes tumor proliferation and metastasis by interacting with proteins such as miRNA and EZH2. In this paper, we review the mechanism of interaction between HOXA11‐AS and various tumors in recent years, and believe that it can be a potential tumor marker and therapeutic target in the future prevention and treatment of tumors.