Cutaneous pseudolymphoma, lymphomatoid contact dermatitis type, as an unusual cause of symmetrical upper eyelid nodules

• Published in: British journal of dermatology (1951) Vol. 143; no. 2; pp. 411 - 414
• Main Authors: Braun, R.P., French, L.E., Feldmann, R., Chavaz, P., Saurat, J‐H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.08.2000; Blackwell; Oxford University Press
• Subjects: Aged; Biological and medical sciences; Chalazion - drug therapy; Dermatitis, Allergic Contact - diagnosis; Dermatitis, Allergic Contact - therapy; Diagnosis, Differential; Drug toxicity and drugs side effects treatment; eyelid; Eyelid Diseases - diagnosis; Eyelid Diseases - therapy; Female; Humans; Lymphoma - diagnosis; lymphomatoid contact dermatitis; Medical sciences; nodule; Pharmacology. Drug treatments; pseudolymphoma; Pseudolymphoma - diagnosis; Pseudolymphoma - therapy; Toxicity: skin, dermoskeleton; Human; Drug; Immunopathology; Allergy; Skin disease; Toxicity; Pseudolymphoma; Nodule; Case study; Contact dermatitis; Skin; Elderly; Upper eyelid
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1046/j.1365-2133.2000.03672.x

We describe a 74‐year‐old woman who rapidly developed bilateral voluminous nodules on the upper eyelids, following 4 months’ treatment for chalazion. Histological and immunohistochemical findings were suggestive of cutaneous pseudolymphoma (CPL), and extensive screening for malignant lymphoma (ML) remained negative. Cutaneous pseudolymphomas are inflammatory diseases that can simulate ML either clinically, histopathologically, or both. They are a rare cause of nodules of the upper eyelids, usually characterized by a benign evolution, that can be secondary to ultraviolet sensitivity, adverse reactions to systemic medications and contact sensitization, among others. In our case, epicutaneous patch tests were strongly positive for a series of allergens contained in the ophthalmological preparations used; therefore, they were suggestive that the patient had CPL, lymphomatoid contact dermatitis type. In addition, the patient had been treated previously with several drugs, known to cause CPL and immune dysregulation. Complete regression of the lesions required treatment with systemic steroids and chlorambucil. No relapse occurred within a 5‐year follow‐up period.