Ultra‐high dimensional variable selection for doubly robust causal inference

• Published in: Biometrics Vol. 79; no. 2; pp. 903 - 914
• Main Authors: Tang, Dingke, Kong, Dehan, Pan, Wenliang, Wang, Linbo
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.06.2023
• Subjects: Alzheimer's disease; average causal effect; ball covariance; Causality; confounder selection; Data analysis; Empirical analysis; Feature selection; Hierarchies; Inference; Medical imaging; Neurodegenerative diseases; Neuroimaging; Prediction models; Predictive analytics; Regression analysis; Regression models; Research methodology; Robustness; variable screening; ball covariance; average causal effect; confounder selection; Alzheimer's disease; variable screening
• ISSN: 0006-341X; 1541-0420
• DOI: 10.1111/biom.13625

Causal inference has been increasingly reliant on observational studies with rich covariate information. To build tractable causal procedures, such as the doubly robust estimators, it is imperative to first extract important features from high or even ultra‐high dimensional data. In this paper, we propose causal ball screening for confounder selection from modern ultra‐high dimensional data sets. Unlike the familiar task of variable selection for prediction modeling, our confounder selection procedure aims to control for confounding while improving efficiency in the resulting causal effect estimate. Previous empirical and theoretical studies suggest excluding causes of the treatment that are not confounders. Motivated by these results, our goal is to keep all the predictors of the outcome in both the propensity score and outcome regression models. A distinctive feature of our proposal is that we use an outcome model‐free procedure for propensity score model selection, thereby maintaining double robustness in the resulting causal effect estimator. Our theoretical analyses show that the proposed procedure enjoys a number of properties, including model selection consistency and pointwise normality. Synthetic and real data analysis show that our proposal performs favorably with existing methods in a range of realistic settings. Data used in preparation of this paper were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.