Optomagnetic Nanoplatforms for In Situ Controlled Hyperthermia

• Published in: Advanced functional materials Vol. 28; no. 11
• Main Authors: Ortgies, Dirk H., Teran, Francisco J., Rocha, Uéslen, de la Cueva, Leonor, Salas, Gorka, Cabrera, David, Vanetsev, Alexander S., Rähn, Mihkel, Sammelselg, Väino, Orlovskii, Yurii V., Jaque, Daniel
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 14.03.2018
• Subjects: Efficiency; Endoscopes; Feedback; Heat generation; Heating; hybrid nanostructures; Hyperthermia; luminescence; magnetic hyperthermia; Materials science; Nanoparticles; nanothermometry; Neodymium; photothermal therapy
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.201704434

Magnetic nanoparticles (M:NPs) are unique agents for in vivo thermal therapies due to their multimodal capacity for efficient heat generation under optical and/or magnetic excitation. Nevertheless, their transfer from laboratory to the clinic is hampered by the absence of thermal feedback and by the influence that external conditions (e.g., agglomeration and biological matrix interactions) have on their heating efficiency. Overcoming these limitations requires, first, the implementation of strategies providing thermal sensing to M:NPs in order to obtain in situ thermal feedback during thermal therapies. At the same time, M:NPs should be modified so that their heating efficiency will be maintained independently of the environment and the added capability for thermometry. In this work, optomagnetic hybrid nanostructures (OMHSs) that simultaneously satisfy these two conditions are presented. Polymeric encapsulation of M:NPs with neodymium‐doped nanoparticles results in a hybrid structure capable of subtissue thermal feedback while making the heating efficiency of M:NPs independent of the medium. The potential application of the OMHSs herein developed for fully controlled thermal therapies is demonstrated by an ex vivo endoscope‐assisted controlled intracoronary heating experiment. The combination of magnetic nanoparticles and luminescent nanothermometers through encapsulation with a polymer into optomagnetic hybrid nanostructures achieves in situ control of thermal therapies inside biological tissues. The magnetic and luminescent properties of the constituting nanoparticles are maintained, and the robustness of the thermal feedback during photothermal and/or magnetic heating is demonstrated.