NMR and conformational studies of new 5-phenylpyrrole-carboxamide derivatives

• Published in: Magnetic resonance in chemistry Vol. 47; no. 12; pp. 1101 - 1109
• Main Authors: López-Cara, Luisa C., de las Infantas, M. José Pineda, Carrión, M. Dora, Camacho, M. Encarnación, Gallo, Miguel A., Espinosa, Antonio, Entrena, Antonio
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2009; Wiley
• Subjects: 13C; 5-phenyl-1H-pyrrole-2-carboxamides; Carbon Isotopes; Chemistry; Chemistry, Multidisciplinary; Chemistry, Physical; Conformational analysis; Derivatives; HMBC; HMQC; Magnetic resonance; Magnetic Resonance Spectroscopy; Molecular Conformation; NMR; NOEDIFF; Nuclear magnetic resonance; Physical Sciences; Protons; Pyrazoles - chemical synthesis; Pyrazoles - chemistry; Reference Standards; Science & Technology; Spectroscopy; Stereoisomerism; Technology; Two dimensional; NMR; C-13; HMQC; HMBC; NOEDIFF; 5-phenyl-1H-pyrrole-2-carboxamides; H-1
• ISSN: 0749-1581; 1097-458X; 1097-458X
• DOI: 10.1002/mrc.2524

The 1H and 13C NMR resonances of 22 5‐(5‐substituted‐2‐nitrophenyl)‐1H‐pyrrole‐2‐carboxamides, 22 5‐(5‐substituted‐2‐aminophenyl)‐1H‐pyrrole‐2‐carboxamides, and 9 5‐phenyl‐1H‐pyrrole‐2‐carboxamides were assigned completely using the concerted application of one‐ and two‐dimensional experiments (DEPT, gs‐HMQC and gs‐HMBC). NOE studies and conformational analysis confirm the preferred conformations of such compounds. Copyright © 2009 John Wiley & Sons, Ltd. The 1H and 13C NMR resonances of 53 5‐(2,5‐disubstitutedphenyl)‐1H‐pyrrole‐2‐carboxamides were assigned completely. NOE studies and conformational analysis confirm the preferred conformation of such compounds.