Gastrointestinal bleeding from enterically drained transplanted pancreas

• Published in: Transplant international Vol. 18; no. 3; pp. 296 - 302
• Main Authors: Orsenigo, Elena, Fiorina, Paolo, Dell'Antonio, Giacomo, Cristallo, Marco, Socci, Carlo, Invernizzi, Laura, Maffi, Paola, Secchi, Antonio, Carlo, Valerio Di
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.03.2005; Blackwell Publishing; Blackwell Publishing Ltd
• Subjects: Adult; Biological and medical sciences; Drainage; enteric drainage; Female; gastrointestinal bleeding; Gastrointestinal Hemorrhage - etiology; General aspects; Graft Survival; Humans; laser‐Doppler flowmetry; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; pancreas transplantation; Pancreas Transplantation - adverse effects; Pancreas Transplantation - mortality; Pharmacology. Drug treatments; Graft(material); Nephrology; Cardiovascular disease; Transplantation; Homotransplantation; Urology; Vascular disease; Laser dopplerometry; Surgery; Graft; Intestinal disease; Flowmetry; Pancreas; Gastric disease; Pharmacology; enteric drainage; laser-Doppler flowmetry; pancreas transplantation; Drain; Drainage; Medicine; Treatment; Bypass; Gastrointestinal bleeding; Digestive diseases
• ISSN: 0934-0874; 1432-2277
• DOI: 10.1111/j.1432-2277.2004.00023.x

Summary Gastrointestinal bleeding has been described as related complication of pancreas transplantation. Of 166 simultaneous pancreas kidney transplantations, 61 were enteric‐drained pancreas transplants (eight done with and 53 without Roux‐en‐Y loop). The patients were divided into two groups according to Roux (group I, n = 8) or no Roux (group II, n = 53) technique. Seven patients experienced anastomotic hemorrhage between the jejunum and duodenal stump (11%), five cases in group I and two in group II (P < 0.001). No relationships between gastrointestinal bleeding duodenal stump and recipient jejunum blood flow, mean pancreatic cold ischemia time, platelet count, and prothrombin time were observed. Donor age over 40 years and abnormal activated partial thromboplastin time constituted risk factors for hemorrhage from the duodenojejunal anastomosis. There were no significant differences in pancreas graft and patient survival rates between the two groups. Anastomotic hemorrhage did not influence patient and graft survival.