Use of chiral auxiliaries in the asymmetric synthesis of biologically active compounds: A review

• Published in: Chirality (New York, N.Y.) Vol. 31; no. 10; pp. 776 - 812
• Main Authors: Diaz‐Muñoz, Gaspar, Miranda, Izabel Luzia, Sartori, Suélen Karine, Rezende, Daniele Cristina, Alves Nogueira Diaz, Marisa
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2019
• Subjects: Amino acids; Asymmetric synthesis; Asymmetry; Bioactive compounds; Biological activity; biologically active compounds; Carbohydrates; chiral auxiliaries; Corey's chiral auxiliary; Evans' oxazolidinones; Modularity; Synthesis; Terpenes; chiral auxiliaries; Corey's chiral auxiliary; Evans' oxazolidinones; asymmetric synthesis; biologically active compounds
• ISSN: 0899-0042; 1520-636X
• DOI: 10.1002/chir.23103

This review article describes the use of some of the most popular chiral auxiliaries in the asymmetric synthesis of biologically active compounds. Chiral auxiliaries derived from naturally occurring compounds, such as amino acids, carbohydrates, and terpenes, are considered essential tools for the construction of highly complex molecules. We highlight the auxiliaries of Evans, Corey, Yamada, Enders, Oppolzer, and Kunz, which led to remarkable progress in asymmetric synthesis in the last decades and continue to bring advances until the present day.