Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids

A new method of electrospray‐assisted laser desorption/ionization (ELDI) mass spectrometry, which combines laser desorption with post‐ionization by electrospray, was applied to rapid analysis of solid materials under ambient conditions. Analytes were desorbed from solid metallic and insulating subst...

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Published inRapid communications in mass spectrometry Vol. 19; no. 24; pp. 3701 - 3704
Main Authors Shiea, Jentaie, Huang, Min-Zon, HSu, Hsiu-Jung, Lee, Chi-Yang, Yuan, Cheng-Hui, Beech, Iwona, Sunner, Jan
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.01.2005
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Summary:A new method of electrospray‐assisted laser desorption/ionization (ELDI) mass spectrometry, which combines laser desorption with post‐ionization by electrospray, was applied to rapid analysis of solid materials under ambient conditions. Analytes were desorbed from solid metallic and insulating substrata using a pulsed nitrogen laser. Post‐ionization produced high‐quality mass spectra characteristic of electrospray, including protein multiple charging. For the first time, mass spectra of intact proteins were obtained using laser desorption without adding a matrix. Bovine cytochrome c and an illicit drug containing methaqualone were chosen in this study to demonstrate the applicability of ELDI to the analysis of proteins and synthetic organic compounds. Copyright © 2005 John Wiley & Sons, Ltd.
Bibliography:istex:C5519D02094AB2D0896C2AD1E372C656B5409AF8
ArticleID:RCM2243
ark:/67375/WNG-0HV78L4N-D
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.2243