Elevation of Creatine Kinase in a Boy Receiving Subcutaneous Injections of Recombinant Human Growth Hormone

A 10-year-old boy with growth hormone (GH) deficiency began to receive subcutaneous injections of recombinant human GH (rhGH) five times a week. Serum creatine kinase (CK) was determined monthly during therapy. Serum CK became abruptly elevated 11 months after the start of GH therapy. Neither myalgi...

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Bibliographic Details
Published inClinical Pediatric Endocrinology Vol. 5; no. 1; pp. 23 - 25
Main Authors Tsuru, Noboru, Inoue, Shuichiro
Format Journal Article
LanguageEnglish
Japanese
Published The Japanese Society for Pediatric Endocrinology 1996
Subjects
growth hormone deficiency
recombinant human growth hormone
serum creatine kinase
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Summary:A 10-year-old boy with growth hormone (GH) deficiency began to receive subcutaneous injections of recombinant human GH (rhGH) five times a week. Serum creatine kinase (CK) was determined monthly during therapy. Serum CK became abruptly elevated 11 months after the start of GH therapy. Neither myalgia nor proximal muscle weakness developed. The CK rapidly returned to a near-normal level within 14 days after the cessation of rhGH injections. The precise etiology of this serum CK elevation is unknown.
ISSN:0918-5739
1347-7358
DOI:10.1297/cpe.5.23