Tissue concentrations of tissue polypeptide antigen (TPA) and prostatic specific antigen (PSA) in 42 patients with prostatic carcinoma

• Published in: The Prostate Vol. 45; no. 4; pp. 299 - 303
• Main Authors: Grande, Mirtha, Carlström, Kjell, Lundh Rozell, Barbro, Eneroth, Peter, Stege, Reinhard, Pousette, Åke
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.12.2000; Wiley-Liss
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; biopsy; Biopsy, Needle; Follow-Up Studies; Humans; Male; Medical sciences; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Nephrology. Urinary tract diseases; Prognosis; prostate; prostate cancer; Prostate-Specific Antigen - metabolism; Prostatic Neoplasms - immunology; Prostatic Neoplasms - pathology; PSA; Survival Analysis; Tissue Polypeptide Antigen - metabolism; TPA; Tumors of the urinary system; Urinary tract. Prostate gland; Human; Cytokeratin; Urinary system disease; Carcinoma; Prognosis; Prostate disease; Tissue polypeptide specific antigen; Tumoral marker; Malignant tumor; Concentration; Prostate specific antigen; Tissue; Male genital diseases; Prostate; Quantitative analysis
• ISSN: 0270-4137; 1097-0045
• DOI: 10.1002/1097-0045(20001201)45:4<299::AID-PROS3>3.0.CO;2-I

BACKGROUND Following development of methods to quantitate biochemical markers in aspiration biopsies we showed that tissue concentration of prostate specific antigen (T‐PSA) decreased with increasing malignancy while serum PSA increased. We also found that T‐PSA predicts the clinical outcome better than earlier used prognostic markers. METHODS In order to further study biochemical markers in prostatic cancer a membrane protein, tissue polypeptide antigen (TPA), which is a complex of polypeptide fragments of cytokeratins 8, 18, and 19, was quantitated in 42 patients with newly diagnosed carcinoma of the prostate. The samples had previously been analyzed for T‐PSA. RESULTS Correlation to TGM classification showed that higher malignancy is correlated to lower tissue TPA values. There is a significant positive correlation (rs = 0.49, P < 0.01) between T‐TPA and T‐PSA. Pretreatment values of T‐PSA, but not T‐TPA, had association to time to progression or time to death. CONCLUSIONS Increasing prostatic malignancy is correlated to decreasing values of T‐TPA. This indicates that the concentrations of membrane and secretory proteins are changed in the same direction in tissue during cancer development. Tissue TPA seem to have no prognostic value in endocrine treatment of prostatic carcinoma. Prostate 45:299–303, 2000. © 2000 Wiley‐Liss, Inc.