Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications

Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization of living cells in vitro. It was found that SiNPs could penetrate into the cells without any cytotoxic effect up to the concentration of 100 μg/ml. The cell cytoplasm was observed to be f...

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Published inJournal of biophotonics Vol. 5; no. 7; pp. 529 - 535
Main Authors Osminkina, Liubov A., Tamarov, Konstantin P., Sviridov, Andrey P., Galkin, Rostislav A., Gongalsky, Maxim B., Solovyev, Valery V., Kudryavtsev, Andrey A., Timoshenko, Victor Yu
Format Journal Article
LanguageEnglish
Published Berlin WILEY-VCH Verlag 01.07.2012
WILEY‐VCH Verlag
Subjects
Animals
bio-imaging
biocompatible
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biocompatible Materials - therapeutic use
Cell Survival - drug effects
Cell Survival - radiation effects
Dogs
Hep G2 Cells
Humans
Luminescent Agents - chemistry
Luminescent Agents - pharmacology
Luminescent Agents - therapeutic use
Luminescent Measurements
Mechanical Phenomena
Metal Nanoparticles
Mice
Molecular Imaging
Nanotechnology
Neoplasms - diagnosis
Neoplasms - pathology
Neoplasms - therapy
NIH 3T3 Cells
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
porous silicon
Silicon - chemistry
Silicon - pharmacology
Silicon - therapeutic use
silicon nanoparticles
Singlet Oxygen - metabolism
theranostics of cancer
Water - chemistry
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Summary:Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization of living cells in vitro. It was found that SiNPs could penetrate into the cells without any cytotoxic effect up to the concentration of 100 μg/ml. The cell cytoplasm was observed to be filled by SiNPs, which exhibited bright photoluminescence at 1.6 eV. SiNPs could also act as photosensitizers of the singlet oxygen generation, which could be used in the photodynamic therapy of cancer. These properties of SiNPs are discussed in view of possible applications in theranostics (both in therapy and in diagnostics). (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Bibliography:istex:3C6406B84E5AB2CB729C1C3D72AC1A98AEEC5C10
ark:/67375/WNG-NF3B0RDD-3
ArticleID:JBIO201100112
Russian Foundation for Basic Research - No. 11-02-90506
Russian Federation Ministry of Education and Science (State Contract No. 16.513.12.3010)
Phone: +007 4967 739 348, Fax: +007 4967 739 348
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201100112