Planned neck dissection for advanced primary head and neck malignancy treated with organ preservation therapy: Disease control and survival outcomes

• Published in: Head & neck Vol. 23; no. 2; pp. 73 - 79
• Main Authors: Newkirk, Kenneth A., Cullen, Kevin J., Harter, K. WIlliam, Picken, Catherine A., Sessions, Roy B., Davidson, Bruce J.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York John Wiley & Sons, Inc 01.02.2001; John Wiley & Sons
• Subjects: Biological and medical sciences; Combined Modality Therapy; Disease-Free Survival; Female; head and neck cancer; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - therapy; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Humans; Male; Medical sciences; Middle Aged; Neck Dissection; organ preservation therapy; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the upper aerodigestive tract; Treatment Outcome; Tumors; Local dissemination; Relapse; Malignant lymphadenopathy; Metastasis; Chemoradiotherapy; Incidence; Conservative surgery; Organ preservation; Surgery; Head and neck; ENT disease; Adult; Lymphatic dissemination; Neck; Dissection; Survival curve; Blood dissemination; Human; Treatment efficiency; Malignant tumor; Radiotherapy; Treatment; Second cancer; Combined treatment; Technique; Predictive factor; Bibliographic review
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/1097-0347(200102)23:2<73::AID-HED1001>3.0.CO;2-6

Background The role of planned neck dissection after organ preservation therapy with radiotherapy or chemotherapy/radiotherapy for advanced head and neck cancers presenting with clinically positive neck disease is still being elucidated. The aim of this study is to review the outcomes of such patients treated by organ preservation therapy at our institution. Methods A retrospective chart review of 33 patients who underwent planned neck dissections after organ preservation therapy for advanced primary head and neck malignancy. Endpoints measured were disease‐free survival and local, regional, and distant control. Setting Tertiary metropolitan medical center. Results Two‐year actuarial disease‐free survival was 61%, and neck control was 92%, with only two failures in the neck. The use of neoadjuvant chemotherapy and total dose of radiotherapy did not correlate with neck control or disease‐free survival. The presence of pathologically positive nodal disease at the time of neck dissection did not correlate with recurrent neck disease, but was a predictor of local recurrence (p = .0086). Conclusions Our data suggest that for patients undergoing planned neck dissection after organ preservation therapy, neck control is obtained in almost all cases. The presence of pathologically positive nodal disease at the time of surgery may have implications for the incidence of local recurrence. © 2001 John Wiley & Sons, Inc., Head Neck 23: 73–79, 2001.