Effect of immunocompromise on metastatic cutaneous squamous cell carcinoma in the parotid and neck

• Published in: Head & neck Vol. 28; no. 3; pp. 244 - 248
• Main Authors: Southwell, Katherine E., Chaplin, John M., Eisenberg, Robert L., McIvor, Nicholas P., Morton, Randall P.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2006; John Wiley & Sons
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - therapy; Facial nerve; Female; Head; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - secondary; Head and Neck Neoplasms - therapy; Hospitals; Humans; immunocompromise; Immunocompromised Host; Immunocompromised hosts; Logistic Models; Male; Medical sciences; Metastases; metastatic; Middle Aged; Neck; Neck Dissection; Neoplasm Recurrence, Local - mortality; New Zealand - epidemiology; Otorhinolaryngology. Stomatology; parotid; Parotid Gland - surgery; Radiotherapy; Radiotherapy, Adjuvant; Regression analysis; Retrospective Studies; Risk factors; SCC; Skin Neoplasms - pathology; squamous cell carcinoma; Survival; New Zealand; Human; Squamous cell carcinoma; Skin disease; Parotid gland; metastatic; Stomatology; ENT; Malignant tumor; Metastasis; Immunosuppression; SCC; immunocompromise; Skin; Neck; parotid
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.20321

Background. Our aim was to examine the effect of a compromised immune state on the outcomes in patients treated for metastatic cutaneous squamous cell carcinoma (SCC). Methods. A retrospective analysis of patients with metastatic cutaneous SCC to the parotid and neck treated at Greenlane Hospital between 1992 and 2002 was conducted. Outcomes were compared between immune‐competent and immunocompromised patients. A logistic regression analysis of likely risk factors for poor outcome was done. Results. Forty‐nine patients were identified, nine of whom were immunocompromised. All patients were treated by parotidectomy and/or neck dissection. The facial nerve was sacrificed in 42% of the patients. Thirty‐seven patients underwent postoperative radiotherapy (76%). Recurrence was significantly more common in the immunocompromised group (56% vs 28%), with higher rates of local and distant recurrence. Survival at 1 and 2 years was reduced. Conclusion. Immunocompromise has a significant impact on the outcome of metastatic cutaneous SCC to the parotid and neck, affecting recurrence and survival. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005