Is obstructive sleep apnea syndrome related to nocturia?

• Published in: Lower urinary tract symptoms Vol. 11; no. 3; pp. 139 - 142
• Main Authors: Arslan, Burak, Gezmis, Cem T., Çetin, Buğra, Gönültas, Serkan, Gökmen, Ersin, Gürkan, Okan, Ozdemir, Enver
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Asia Pty Ltd 01.05.2019; Wiley Subscription Services, Inc
• Subjects: Adult; Age Factors; benign prostatic hyperplasia; Dyspnea; Dyspnea - complications; Humans; Hyperplasia; Male; Middle Aged; nocturia; Nocturia - etiology; nocturnal polyuria; obstructive sleep apnea; Polysomnography; Prostate; Prostatic Hyperplasia - complications; Prostatism - etiology; Retrospective Studies; Risk Factors; Severity of Illness Index; Sleep apnea; Sleep Apnea, Obstructive - complications; Sleep Apnea, Obstructive - diagnosis; Sleep disorders; Smoking; Urine; obstructive sleep apnea; nocturia; nocturnal polyuria; benign prostatic hyperplasia
• ISSN: 1757-5664; 1757-5672
• DOI: 10.1111/luts.12250

Objective The aim of this study was to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). Methods This multicenter study was performed on 122 male patients with dyspnea and/or sleep disorder. Patient characteristics were recorded. All patients underwent full‐night polysomnography, and the apnea–hypopnea index (AHI) was calculated. LUTS were evaluated using the International Prostate Symptom Score (IPSS) and prostate volume was calculated by transabdominal ultrasonography. Based on the AHI, patients were classified as normal or as having mild, moderate, or severe OSAS. Regression analyses were performed to identify independent predictive factors associated with nocturia. Results Severe, moderate, and mild OSAS was present in 53, nine, and 46 patients, respectively, where 14 patients with dyspnea and sleep disorder were classified as normal. There were no significant differences between the severe and mild OSAS groups with regard to age, body mass index, systolic and diastolic blood pressure, smoking history, fluid intake, and serum creatinine and glucose concentrations. However, there was a significant difference between two groups in AHI (P < 0.001), nocturia (P < 0.001), and nocturnal voided volume (P = 0.011). Univariate and multivariate analyses revealed that age, smoking history, and an AHI >15 were independent predictors of nocturia. Conclusions Sleep disorders are thought to be one reason for nocturia and nocturnal polyuria. Thus, OSAS must be considered in BPH patients who predominantly have storage symptoms.