Plasmodium falciparum: Further Characterization of Putative Cation ATPases

• Published in: Experimental parasitology Vol. 78; no. 1; pp. 113 - 117
• Main Authors: Krishna, S., Cowan, G.M., Robson, K.J., Meade, J.C.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.02.1994; Elsevier
• Subjects: adenosina trifosfatasa; adenosine triphosphatase; Adenosine Triphosphatases - chemistry; Adenosine Triphosphatases - genetics; Amino Acid Sequence; Animals; Base Sequence; Biochemistry. Physiology. Immunology. Molecular biology; Biological and medical sciences; Blotting, Northern; Blotting, Southern; dna hybridization; DNA, Protozoan - chemistry; Fundamental and applied biological sciences. Psychology; hibridacion de adn; hybridation d' adn; Invertebrates; Molecular Sequence Data; nucleotide sequence; Plasmodium falciparum; Plasmodium falciparum - enzymology; Plasmodium falciparum - genetics; Protozoa; Repetitive Sequences, Nucleic Acid; RNA, Messenger - chemistry; secuencia nucleica; Sequence Alignment; sequence nucleique; Protozoa; Protozoal disease; Malaria; Enzyme; Adenosinetriphosphatase; Parasite; Gene expression; Infection; Characterization; Plasmodium falciparum; Pathogenic; Hydrolases; Sporozoa; Aminoacid sequence
• ISSN: 0014-4894; 1090-2449
• DOI: 10.1006/expr.1994.1011

The emergence of multi-drug resistant strains of Plasmodium falciparum and the current lack of a vaccine have stimulated research to identify new chemotherapeutic targets. We have focused on the isolation and characterization of nucleotide sequences encoding putative "P"-type cation ATPases from P. falciparum. Selective inhibitors of mammalian members of this transporter family are well studied, and some are already in clinical use.