Therapeutic effects of ecabet sodium, an antiulcer drug, on dextran sodium sulfate-induced ulcerative colitis in rats

• Published in: Digestive diseases and sciences Vol. 50; no. 5; pp. 922 - 927
• Main Authors: NOTO, Tsunehisa, YAMADA, Hiroshi, INUI, Takashi, OKUYAMA, Kayoko, WATANABLE, Ayako, KIMURA, Isami, NAGASAKI, Masaaki
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.05.2005; Springer Nature B.V
• Subjects: Administration, Rectal; Animals; Anti-Ulcer Agents - administration & dosage; Biological and medical sciences; Cell Culture Techniques; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - pathology; Dextran Sulfate; Disease Models, Animal; Diterpenes, Abietane - administration & dosage; Enema; Enterocytes - drug effects; Enterocytes - physiology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Male; Medical sciences; Neutrophils - drug effects; Neutrophils - physiology; Other diseases. Semiology; Rats; Rats, Sprague-Dawley; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Restitution; Rat; Enzyme; Rodentia; Antiulcer agent; Inflammatory disease; Dextran; Ecabet; Vertebrata; Mammalia; Treatment; Leukotriene B4; Blood substitute; Animal; Sodium sulfate; TGFβ; Digestive diseases; Intestinal disease; Oxidoreductases; Lipoxygenase; 5-lipoxygenase; Ulcerative colitis
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-005-2665-y

Ecabet, an antiulcer drug, is reported to be effective in patients with ulcerative colitis. We investigated the effect of ecabet enema on ulcerative colitis in rats and some mechanisms underlying this effect. In vivo ecabet enema showed a therapeutic effect in the rat ulcerative colitis model induced by dextran sodium sulfate in the drinking water. The amount of ecabet bound to damaged mucosa was higher than that bound to normal mucosa 30 min after intrarectal administration. In vitro ecabet accelerated the restitution of epithelial cells, which was not affected by a TGF-beta antibody. Ecabet inhibited the leukotriene B4 production and 5-lipoxygenase activity in human neutrophils. In conclusion, ecabet enema showed a therapeutic effect in rats with ulcerative colitis. This effect may be attributable to the high binding affinity for damaged mucosa, the acceleration of restitution, and the inhibition of leukotriene B4 production.