Puncture injection of para-toluenesulfonamide combined with chemoembolization for advanced hepatocellular carcinoma

Hepatocellular carcinoma （HCC） is difficult to eradicate due to its resilient nature. Portal vein is often involved in tumors of large size, which exclude the patient from surgical resection and local ablative therapy, such as percutaneous ethanol injection （PEI） and radiofrequency ablation （RFA） be...

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Published inWorld journal of gastroenterology : WJG Vol. 18; no. 46; pp. 6861 - 6864
Main Authors He, Qing, Kuang, An-Ren, Guan, Yong-Song, Liu, Yue-Qing
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 14.12.2012
Subjects
Aged
Antineoplastic Agents - pharmacology
Carcinoma, Hepatocellular - drug therapy
Case Report
Catheter Ablation - methods
Chemoembolization, Therapeutic - methods
Humans
Liver Neoplasms - drug therapy
Male
Necrosis
Prognosis
Punctures
Sulfonamides - administration & dosage
Toluene - administration & dosage
Toluene - analogs & derivatives
Treatment Outcome
化疗
对甲苯磺酰胺
晚期
栓塞
注射剂
穿刺
肝动脉
肝癌
Therapy
Hepatocellular carcinoma
Para-toluenesulfonamide
Antitumor agent
Transcatheter arterial chemoembolization
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Summary:Hepatocellular carcinoma （HCC） is difficult to eradicate due to its resilient nature. Portal vein is often involved in tumors of large size, which exclude the patient from surgical resection and local ablative therapy, such as percutaneous ethanol injection （PEI） and radiofrequency ablation （RFA） because they were considered neither effective nor safe. Currently, there is almost no effective treatment for HCC of such condition. As a unique antitumor agent in form of lipophilic fluid for local injection, para-toluenesulfonamide （PTS） produces mild side effects while necrotizing the tumor tissues quickly and efficiently. Being largely different from both PEI and RFA therapies, PTS can disseminate itself in tumors more easily than other caustic agents, such as alcohol. So PTS may offer additional benefit to HCCs with vascular involvement. We herein describe a 70-year-old HCC patient who was treated with the combination of PTS injection and transcatheter arterial chemoembolization, resulting in a significantly improved clinical prognosis.
Bibliography:14-1219/R
Hepatocellular carcinoma （HCC） is difficult to eradicate due to its resilient nature. Portal vein is often involved in tumors of large size, which exclude the patient from surgical resection and local ablative therapy, such as percutaneous ethanol injection （PEI） and radiofrequency ablation （RFA） because they were considered neither effective nor safe. Currently, there is almost no effective treatment for HCC of such condition. As a unique antitumor agent in form of lipophilic fluid for local injection, para-toluenesulfonamide （PTS） produces mild side effects while necrotizing the tumor tissues quickly and efficiently. Being largely different from both PEI and RFA therapies, PTS can disseminate itself in tumors more easily than other caustic agents, such as alcohol. So PTS may offer additional benefit to HCCs with vascular involvement. We herein describe a 70-year-old HCC patient who was treated with the combination of PTS injection and transcatheter arterial chemoembolization, resulting in a significantly improved clinical prognosis.
Hepatocellular carcinoma Para-toluenesulfonamide Antitumor agent Transcatheter arterial chemoembolization Therapy
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Correspondence to: Dr. An-Ren Kuang, Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. he41@sohu.com
Telephone: +86-28-85423270 Fax: +86-28-85423278
Author contributions: He Q and Kuang AR conceived and designed the study and prepared the manuscript; Guan YS and Liu YQ acquired and analyzed the data.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v18.i46.6861