Trans-corneal drug delivery strategies in the treatment of ocular diseases

[Display omitted] The cornea is a remarkable tissue that possesses specialized structures designed to safeguard the eye against foreign objects. However, its unique properties also make it challenging to deliver drugs in a non-invasive manner. This review highlights recent advancements in achieving...

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Published inAdvanced drug delivery reviews Vol. 198; p. 114868
Main Authors Li, Liping, Jia, Fan, Wang, Youxiang, Liu, Jiamin, Tian, Yi, Sun, Xinghuai, Lei, Yuan, Ji, Jian
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2023
Subjects
Biological Transport
Cornea
Drug delivery
Drug Delivery Systems
Humans
Nanomaterials
Nanostructures
Natural barrier
Ocular therapy
Pharmaceutical Preparations
Nanomaterials
Cornea
Drug delivery
Ocular therapy
Natural barrier
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Summary:[Display omitted] The cornea is a remarkable tissue that possesses specialized structures designed to safeguard the eye against foreign objects. However, its unique properties also make it challenging to deliver drugs in a non-invasive manner. This review highlights recent advancements in achieving highly efficient drug transport across the cornea, focusing on nanomaterials. We have classified these strategies into three main categories based on their mechanisms and have analyzed their success and limitations in a systematic manner. The purpose of this review is to examine potential general principles that could improve drug penetration through the cornea and other natural barriers in the eye. We hope it will inspire the development of more effective drug delivery systems that can better treat ocular diseases.
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ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2023.114868