Highly sensitive and selective erythromycin nanosensor employing fiber optic SPR/ERY imprinted nanostructure: Application in milk and honey

• Published in: Biosensors & bioelectronics Vol. 90; pp. 516 - 524
• Main Authors: Shrivastav, Anand M., Usha, Sruthi P., Gupta, Banshi D.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.04.2017
• Subjects: Animals; Biosensing Techniques; Chromium; Erythromycin; Erythromycin - chemistry; Erythromycin - isolation & purification; Fiber Optic Technology; Fiber optics; Food Contamination - analysis; Honey - analysis; Limit of Detection; Milk; Milk - chemistry; Molecular imprinted nanoparticles; Nanoparticles; Nanostructure; Nanostructures - chemistry; Optical fiber; Optical fibers; Sensor; Sensors; Silver - chemistry; Surface Plasmon Resonance; Surface plasmon resonance; Erythromycin; Molecular imprinted nanoparticles; Optical fiber; Sensor
• ISSN: 0956-5663; 1873-4235
• DOI: 10.1016/j.bios.2016.10.041

An erythromycin (ERY) detection method is proposed using the fiber optic core decorated with the coatings of silver and an over layer of ERY imprinted nanoparticles. Synthesis of ERY imprinted nanoparticles is carried out using miniemulsion method. The operating range of the sensor is observed to be from 1.62×10−3 to 100µM while the sensor possesses the linear response for ERY concentration range from 0.1 to 5µM. The sensing method shows a maximum sensitivity of 205nm/µM near ERY concentration of 0.01µM. The detection limit and the quantification limit of the sensor are found to be 1.62×10−3µM and 6.14×10−3µM, respectively. The sensor’s applicability in real samples is also examined and is found to be in good agreement for the industrial application. The sensor possesses numerous advantages like fast response time (<15s), simple, low cost, highly selective along with abilities towards online monitoring and remote sensing of analyte. •Erythromycin (ERY) sensor is proposed using Ag and ERY imprinted Nps layers.•The sensor operates from 1.62×10−3 to 100µM concentration.•The detection limit of the sensor is 1.62×10−3µM.•The sensor shows its applicability in the real samples like milk and honey.•The sensor is highly selective and sensitive with small response time.