Biomedical analytical monitor of artificial kidney operation: Monitoring of creatinine removal

[Display omitted] •A flow analysis system for hemodialysis monitoring has been developed.•The system can operate as a discrete as well as a continuous monitor.•The monitor has been dedicated for monitoring of creatinine removal.•The monitor has been validated with real postdialysate samples.•A simul...

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Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 128; pp. 28 - 34
Main Authors Michalec, Michał, Tymecki, Łukasz, Koncki, Robert
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 05.09.2016
Subjects
Body Fluids - chemistry
Creatinine
Creatinine - chemistry
Flow analysis
Flow Injection Analysis - methods
Hemodialysis
Humans
Kidney - metabolism
Kidneys, Artificial
Monitoring
Optoelectronic detector
Renal Dialysis - methods
Optoelectronic detector
Creatinine
Hemodialysis
Monitoring
Flow analysis
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Summary:[Display omitted] •A flow analysis system for hemodialysis monitoring has been developed.•The system can operate as a discrete as well as a continuous monitor.•The monitor has been dedicated for monitoring of creatinine removal.•The monitor has been validated with real postdialysate samples.•A simulator of hemodialysis progress has been developed. A general concept for the development of flow analysis system for non-invasive, bloodless monitoring of uremic toxins’ removal in the course of clinical hemodialysis treatment is presented. The monitor operates in both (discrete and continuous) modes of measurements. In this study as a model uremic marker creatinine has been chosen. The monitor is based on solenoid operated microdevices (pumps and valves) and an optoelectronic flow-through detector made of paired light emitting diodes allowing photometric determination of this metabolite using Jaffé method. Additionally, a simple two microsolenoid pump-based module allowing the modeling of toxin removal by artificial kidney has been developed. The developed monitor has been validated with real samples of postdialysate fluid produced by artificial kidney in the course of clinical hemodialysis treatment. The results of hemodialysis monitoring are fully comparable with those obtained using reference off-line method.
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ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2016.04.021