Retrograde Axonal Transport in the Central Nervous System

When horseradish peroxidase is injected into the optic tectum of a chick, axons of ganglion cells transport it centripetally to their cell bodies in the retina at a rate of about 72 millimeters per day. After intraocular injections in the young chick, the peroxidase is transported centripetally alon...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 176; no. 4042; pp. 1416 - 1417
Main Authors LaVail, Jennifer H., LaVail, Matthew M.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 30.06.1972
Subjects
Animals
Axons
Axons - metabolism
Biological markers
Cell nucleus
Central nervous system
Chickens
Enzymes
Eye
Eyes
Ganglia
Injections
Neurons
Optic Nerve - metabolism
Peroxidases - administration & dosage
Peroxidases - metabolism
Retina
Retina - metabolism
Superior colliculus
Time Factors
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Summary:When horseradish peroxidase is injected into the optic tectum of a chick, axons of ganglion cells transport it centripetally to their cell bodies in the retina at a rate of about 72 millimeters per day. After intraocular injections in the young chick, the peroxidase is transported centripetally along efferent axons, and is concentrated in cell bodies within the isthmo-optic nucleus. This retrograde movement of protein from axon terminal to cell body suggests a possible mechanism by which neurons respond to their target areas.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.176.4042.1416