Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes

• Published in: Chemical science (Cambridge) Vol. 8; no. 1; pp. 40 - 62
• Main Authors: Almond-Thynne, Joshua, Blakemore, David C, Pryde, David C, Spivey, Alan C
• Format: Journal Article
• Language: English
• Published: England 01.01.2017
• Subjects: Aromatic compounds; Chemical reactions; Coupling; Halides; Searching; Trends

Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactio...