Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes

Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactio...

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Bibliographic Details
Published inChemical science (Cambridge) Vol. 8; no. 1; pp. 40 - 62
Main Authors Almond-Thynne, Joshua, Blakemore, David C, Pryde, David C, Spivey, Alan C
Format Journal Article
LanguageEnglish
Published England 01.01.2017
Subjects
Aromatic compounds
Chemical reactions
Coupling
Halides
Searching
Trends
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Summary:Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
Bibliography:ObjectType-Article-1
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ISSN:2041-6520
2041-6539
DOI:10.1039/c6sc02118b