Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and kidney stone: evidence from NHANES 2007–2018

• Published in: BMC public health Vol. 24; no. 1; pp. 1 - 9
• Main Authors: Chen, Tao, Cheng, Yu, Song, Zheng, Zhang, Gan, Zeng, Tao, Chao, Haichao
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 08.07.2024; BioMed Central; BMC
• Subjects: Atherosclerosis; Body mass index; Calculi; Cardiovascular diseases; Cholesterol; Cholesterol, HDL; Cross-sectional studies; Cross-sectional study; Diabetes; Diabetes mellitus; Health aspects; Health risks; High density; High density lipoprotein; Hypertension; Insulin resistance; Kidney stones; Kidneys; Lipid ratio; Lipids; Lipoproteins; Measurement; Metabolic disorders; Metabolic syndrome; Nephrolithiasis; NHHR; Quartiles; RCS; Regression analysis; Risk analysis; Risk factors; Spline functions; Statins; Statistical analysis; Subgroups; Surveys; Uric acid; United States
• ISSN: 1471-2458; 1471-2458
• DOI: 10.1186/s12889-024-19265-4

Abstract Background As an innovative lipid parameter, NHHR (the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol) can serve as a valuable tool for assessing cardiovascular disease risk. Nevertheless, the relationship between NHHR and the risk of kidney stones remains unexplored. Methods A cross-sectional survey utilized data from the National Health and Population Survey (NHANES) database in the United States spanning from 2007 to 2018. Distinct statistical analyses were applied, including weighted logistic regression, stratified and interaction analysis and restricted cubic spline curve (RCS) models, to examine the correlation between NHHR and the incidence of kidney stones. Results This analysis encompassed 24,664 participants, with 9.63% reporting incidents of kidney stones. Following multivariate logistic regression and comprehensive adjustments, participants in NHHR quartile 4 (OR 1.34; 95% CI 1.12, 1.60, P < 0.01) exhibited a significantly increased risk of kidney stones compared to those in NHHR quartile 1 (Q1). The RCS result further illustrated a non-linear correlation between NHHR and the incidence of kidney stones. The result of subgroup analysis manifested that participants without diabetes had a higher risk of kidney stones when measured high NHHR levels compared those with diabetes ( p for interaction < 0.05). Conclusion Elevated NHHR levels were found to be associated with an increased risk of kidney stones. Based on these findings, NHHR appears to be a promising predictive indicator for the occurrence of kidney stones.