Anti-prion antibodies for prophylaxis following prion exposure in mice
Prion disease is characterized by a conformational change of the normal form of the prion protein (PrP C) to the scrapie-associated form (PrP Sc). Since the emergence of new variant Creutzfeldt-Jakob disease a potentially large human population is at risk for developing prion disease. Currently, no...
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Published in | Neuroscience letters Vol. 336; no. 3; pp. 185 - 187 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
23.01.2003
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Prion disease is characterized by a conformational change of the normal form of the prion protein (PrP
C) to the scrapie-associated form (PrP
Sc). Since the emergence of new variant Creutzfeldt-Jakob disease a potentially large human population is at risk for developing prion disease. Currently, no effective treatment or form of post-exposure prophylaxis is available for prion disease. We recently showed that active immunization with recombinant PrP prolongs the incubation period of scrapie. Here we show that anti-PrP antibodies following prion exposure are effective at increasing the incubation period of the infection. Stimulation of the immune system is an important therapeutic target for the prion diseases, as well as for other neurodegenerative illnesses characterized by abnormal protein conformation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/S0304-3940(02)01192-8 |