Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 84; no. 3; pp. 472 - 478
• Main Authors: Forbes, D.C., Creixell, M., Frizzell, H., Peppas, N.A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2013
• Subjects: Animals; ARGET ATRP; Cationic polymer; Cations; Cell Line; Cell Line, Tumor; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug delivery; Emulsions; Fluorescein - pharmacology; Hemolysis; Humans; Hydrogel; Hydrogels - chemistry; Hydrogen-Ion Concentration; Light; Mice; Microscopy, Electron, Transmission; Nanomedicine - methods; Nanoparticle; Nanoparticles - chemistry; Polyamines - chemical synthesis; Polyamines - chemistry; RNA, Small Interfering - metabolism; Scattering, Radiation; Time Factors; Ultraviolet Rays; UV-initiated polymerization; Cationic polymer; UV-initiated polymerization; Drug delivery; Hydrogel; Nanoparticle; ARGET ATRP
• ISSN: 0939-6411; 1873-3441
• DOI: 10.1016/j.ejpb.2013.01.007

Representation of the polycationic nanoparticle and of the biomaterial property comparisons for ARGET ATRP and UV-initiated formulations (with 30mol of hydrophobic tBMA monomer per 100mol cationic DEAEMA monomer in the feed). [Display omitted] This work provides a systemic comparison for ARGET ATRP and UV-initiated polycationic nanoparticles for drug delivery and a guide to deciding which type of polycationic nanoparticles have the best properties for specific applications. Polycationic nanoparticles were synthesized using a previously developed UV-initiated photoemulsion polymerization or a newly developed ARGET ATRP synthesis technique. The effect of the ratio of hydrophobic monomer in the feed was evaluated. Increasing the feed ratio of hydrophobic monomer was necessary to maintain biocompatibility and pH-responsive membrane disruptive characteristics when switching from the UV-initiated polymerization to ARGET ATRP. The resulting polycationic nanoparticles have utility as drug delivery carriers for hydrophobic drugs and/or nucleic acids.