MRI-measured periprostatic to subcutaneous adipose tissue thickness ratio as an independent risk factor in prostate cancer patients undergoing radical prostatectomy

• Published in: Scientific reports Vol. 14; no. 1; pp. 20896 - 11
• Main Authors: Jiang, Shanshan, Li, Yi, Guo, Yusheng, Gong, Bingxin, Wei, Chengcheng, Liu, Weiwei, Chen, Chao, Pan, Feng, Song, Jiyu, He, Qingliu, Yang, Lian, Zhou, Guofeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.09.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4028; 692/4028/67; 692/4028/67/589; 692/4028/67/589/466; Adipose tissue; Aged; Biochemical recurrence; Body fat; Humanities and Social Sciences; Humans; Laparoscopic radical prostatectomy; Laparoscopy; Magnetic Resonance Imaging - methods; Male; Medical prognosis; Middle Aged; multidisciplinary; Neoplasm Recurrence, Local - diagnostic imaging; Neoplasm Recurrence, Local - pathology; Patients; Periprostatic adipose tissue thickness; Prognosis; Prostate - diagnostic imaging; Prostate - pathology; Prostate - surgery; Prostate cancer; Prostatectomy; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Regression analysis; Retrospective Studies; Risk Factors; Science; Science (multidisciplinary); Subcutaneous adipose tissue thickness; Subcutaneous Fat - diagnostic imaging; Subcutaneous Fat - pathology; Survival; Laparoscopic radical prostatectomy; Prognosis; Prostate cancer; Biochemical recurrence; Periprostatic adipose tissue thickness; Subcutaneous adipose tissue thickness
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-71862-w

The purpose of this study is to evaluate whether the periprostatic adipose tissue thickness (PPATT) is an independent prognostic factor for prostate cancer patients after laparoscopic radical prostatectomy (LRP). This retrospective cohort study included consecutive prostate cancer patients who underwent LRP treatment at Wuhan Union Hospital from June 2, 2016, to September 7, 2023. PPATT was defined as the thickness of periprostatic fat and was obtained by measuring the shortest vertical distance from the pubic symphysis to the prostate on the midsagittal T2-weighted MR images. Subcutaneous adipose tissue thickness (SATT) was obtained by measuring the shortest vertical distance from the pubic symphysis to the skin at the same slice with PPATT. The primary outcome of the study was biochemical recurrence (BCR), and the secondary outcome was overall survival (OS). Multivariable Cox regression analysis was used to identify independent prognostic factors for prostate cancer survival and prognosis. Based on the optimal cutoff value, 162 patients were divided into a low PPATT/SATT group (n = 82) and a high PPATT/SATT group (n = 80). During the entire follow-up period (median 23.5 months), 26 patients in the high PPATT/SATT group experienced BCR (32.5%), compared to 18 in the low PPATT/SATT group (22.0%). Kaplan–Meier curve analysis indicated that the interval to BCR was significantly shorter in the high PPATT/SATT group ( P  = 0.037). Multivariable Cox regression analysis revealed that an increase in the PPATT/SATT ratio was associated with BCR (hazard ratio: 1.90, 95% CI, 1.03–3.51; P  = 0.040). The PPATT/SATT ratio is a significant independent risk factor for BCR after LRP for prostate cancer patients.