The role of the TGF-β1 signaling pathway in the process of amelogenesis

• Published in: Frontiers in physiology Vol. 16; p. 1586769
• Main Authors: Ma, Xiaoxue, Ma, Yunjing, Lin, Zhiyong, Ji, Mei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.04.2025
• Subjects: ameloblast; amelogenesis; circadian clock; enamel development; enamel formation; Physiology; TGF-β1; TGF-β1; ameloblast; enamel formation; enamel development; circadian clock; amelogenesis

Amelogenesis is a highly regulated process involving multiple signaling pathways, among which the transforming growth factor-β1 (TGF-β1) signaling pathway plays a pivotal role in enamel formation. This review firstly elucidates the critical functions of TGF-β1 in regulating ameloblast behavior and e...