The role of the TGF-β1 signaling pathway in the process of amelogenesis

Amelogenesis is a highly regulated process involving multiple signaling pathways, among which the transforming growth factor-β1 (TGF-β1) signaling pathway plays a pivotal role in enamel formation. This review firstly elucidates the critical functions of TGF-β1 in regulating ameloblast behavior and e...

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Published inFrontiers in physiology Vol. 16; p. 1586769
Main Authors Ma, Xiaoxue, Ma, Yunjing, Lin, Zhiyong, Ji, Mei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 09.04.2025
Subjects
ameloblast
amelogenesis
circadian clock
enamel development
enamel formation
Physiology
TGF-β1
TGF-β1
ameloblast
enamel formation
enamel development
circadian clock
amelogenesis
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Summary:Amelogenesis is a highly regulated process involving multiple signaling pathways, among which the transforming growth factor-β1 (TGF-β1) signaling pathway plays a pivotal role in enamel formation. This review firstly elucidates the critical functions of TGF-β1 in regulating ameloblast behavior and enamel development, encompassing ameloblast proliferation, differentiation, apoptosis, enamel matrix protein synthesis, and mineralization. Secondly, based on emerging evidence, we further discuss potential interactions between TGF-β signaling and circadian regulation in enamel formation, although this relationship requires further experimental validation. Finally, future research directions are proposed to further investigate the relationship between TGF-β1 and the circadian clock in the context of amelogenesis.
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Reviewed by: Rucha Arun Bapat, University of Southern California, United States
Sanjiv Neupane, Stony Brook University, United States
Edited by: Janet Moradian-Oldak, University of Southern California, United States
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2025.1586769