Recent advances in the synthesis of ent -kaurane diterpenoids

Covering: 2015 to 2020The -kaurane diterpenoids are integral parts of tetracyclic natural products that are widely distributed in terrestrial plants. These compounds have been found to possess interesting bioactivities, ranging from antitumor, antifungal and antibacterial to anti-inflammatory activi...

Full description

Saved in:
Bibliographic Details
Published inNatural product reports Vol. 39; no. 1; pp. 119 - 138
Main Authors Zhao, Xiangbo, Cacherat, Bastien, Hu, Qifei, Ma, Dawei
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 26.01.2022
Subjects
Chemistry Techniques, Synthetic - methods
Covalent bonds
Diterpenes
Diterpenes - chemical synthesis
Diterpenes, Kaurane - chemical synthesis
Fungicides
Inflammation
Natural products
Synthesis
Terrestrial environments
Online AccessGet full text

Cover

More Information
Summary:Covering: 2015 to 2020The -kaurane diterpenoids are integral parts of tetracyclic natural products that are widely distributed in terrestrial plants. These compounds have been found to possess interesting bioactivities, ranging from antitumor, antifungal and antibacterial to anti-inflammatory activities. Structurally, the different tetracyclic moieties of -kauranes can be seen as the results of intramolecular cyclizations, oxidations, C-C bond cleavages, degradation, or rearrangements, starting from their parent skeleton. During the past decade, great efforts have been made to develop novel strategies for synthesizing these natural products. The purpose of this review is to describe the recent advances in the total synthesis of -kaurane diterpenoids covering the period from 2015 to date.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0265-0568
1460-4752
DOI:10.1039/d1np00028d