Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modificati...

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Published inChemical communications (Cambridge, England) Vol. 53; no. 23; pp. 3303 - 3306
Main Authors Tian, Xiaohe, Zhu, Yingzhong, Zhang, Mingzhu, Luo, Lei, Wu, Jieying, Zhou, Hongping, Guan, Lijuan, Battaglia, Giuseppe, Tian, Yupeng
Format Journal Article
LanguageEnglish
Published England 2017
Subjects
Absorption
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Antineoplastic Agents - radiation effects
Cell Nucleus - metabolism
Coordination Complexes - chemical synthesis
Coordination Complexes - pharmacology
Coordination Complexes - radiation effects
DNA - genetics
DNA Damage - drug effects
Efficiency
Endocytosis - drug effects
Female
Hep G2 Cells
Humans
Iridium - chemistry
Iridium - radiation effects
Iridium compounds
Localization
Mice, Inbred BALB C
Mitochondria
Mitochondria - metabolism
Nuclei
Photochemotherapy
Photodynamic therapy
Terminals
Ultraviolet Rays
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Summary:We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09470h