Dental mesenchymal stem cells

Mammalian teeth harbour mesenchymal stem cells (MSCs), which contribute to tooth growth and repair. These dental MSCs possess many in vitro features of bone marrow-derived MSCs, including clonogenicity, expression of certain markers, and following stimulation, differentiation into cells that have th...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 143; no. 13; pp. 2273 - 2280
Main Author Sharpe, Paul T
Format Journal Article
LanguageEnglish
Published England 01.07.2016
Subjects
Animals
Humans
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Minerals - metabolism
Tooth - cytology
Translational Medical Research
Wound Healing
MSCs
Incisor
Dental
Teeth
Pulp
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Summary:Mammalian teeth harbour mesenchymal stem cells (MSCs), which contribute to tooth growth and repair. These dental MSCs possess many in vitro features of bone marrow-derived MSCs, including clonogenicity, expression of certain markers, and following stimulation, differentiation into cells that have the characteristics of osteoblasts, chondrocytes and adipocytes. Teeth and their support tissues provide not only an easily accessible source of MSCs but also a tractable model system to study their function and properties in vivo In addition, the accessibility of teeth together with their clinical relevance provides a valuable opportunity to test stem cell-based treatments for dental disorders. This Review outlines some recent discoveries in dental MSC function and behaviour and discusses how these and other advances are paving the way for the development of new biologically based dental therapies.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.134189