A multifunctional mesoporous silica-gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay

Breast cancer is the most common malignancy and also the second leading cause of cancer mortality in women globally. Strategies for early and precise detection of breast cancer cells are highly desired in breast cancer diagnosis and treatment. Here, we report on the efficient detection of HER2-posit...

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Published inNanoscale Vol. 11; no. 6; pp. 2631 - 2636
Main Authors Li, Mingqiang, Lao, Yeh-Hsing, Mintz, Rachel L, Chen, Zhuanggui, Shao, Dan, Hu, Hanze, Wang, Hong-Xia, Tao, Yu, Leong, Kam W
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 14.02.2019
Subjects
Amplification
Antibodies
Biosensors
Breast cancer
Cancer
Catalysis
Colorimetry
Diagnosis
Gold
Nanoclusters
Nanoparticles
Peroxidase
Selectivity
Silicon dioxide
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Summary:Breast cancer is the most common malignancy and also the second leading cause of cancer mortality in women globally. Strategies for early and precise detection of breast cancer cells are highly desired in breast cancer diagnosis and treatment. Here, we report on the efficient detection of HER2-positive (HER2+) breast cancer cells using an amplified signal scheme enabled by gold nanoclusters entrapped in mesoporous silica nanoparticles (MSNs). The utilization of MSNs as an excellent enzyme immobilization support and gold nanoclusters as an effective peroxidase mimic imparts high sensitivity to this detection platform. In addition, the inclusion of target-specific HER2 antibodies adds excellent selectivity. Determination of HER2+ cancer cells in breast cancer tissue demonstrates the potential application of this biosensor design in clinical diagnosis in particular, and bioanalysis in general.
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ISSN:2040-3364
2040-3372
DOI:10.1039/c8nr08337a