Solution chemistry and cytotoxic properties of novel organogold(III) compounds

• Published in: Bioorganic & medicinal chemistry Vol. 12; no. 23; pp. 6039 - 6043
• Main Authors: Messori, Luigi, Marcon, Giordana, Cinellu, Maria Agostina, Coronnello, Marcella, Mini, Enrico, Gabbiani, Chiara, Orioli, Pierluigi
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2004; Elsevier Science
• Subjects: 1H NMR spectroscopy; Antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cancer; Cell Line, Tumor; Cell Proliferation - drug effects; Cytotoxicity; General aspects; Gold; Gold - chemistry; Gold - pharmacology; Gold - therapeutic use; Humans; Inhibitory Concentration 50; Medical sciences; Molecular Structure; Organogold(III) complexes; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Organometallic Compounds - therapeutic use; Pharmacology. Drug treatments; Solutions; Structure-Activity Relationship; UV–vis absorption spectroscopy; Gold; Cytotoxicity; 1H NMR spectroscopy; Organogold(III) complexes; UV–vis absorption spectroscopy; Cancer; Antineoplastic agent; Aryl complex; Human; Carcinoma; Gold III Organic compounds; Lung; Organic ligand; Bipyridines; Trivalent metal Complexes; In vitro; Biological activity; Pyridine derivatives; Cell line; Gold III Complexes; Pyrazole derivatives; Colon; Mammary gland; Chemical synthesis; Tumor cell
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2004.09.014

[Display omitted] The solution behaviour of some novel organogold(III) compounds was investigated, and their cytotoxic properties evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following compounds were considered: [Au(bipydmb-H)(2,6-xylidine-H)][PF6] (AuXyl) and [Au(bipydmb-H)(p-toluidine-H)][PF6] (AuTol) (in which bipydmb=6-(1,1-dimethylbenzyl)-2,2′-bipyridine), [Au(pydmb-H)(AcO)2] (AuPyAcO) (in which pydmb=2-(1,1-dimethylbenzyl)-pyridine) and [Au(pzPh-H)Cl3]K (AuPzCl) (in which pzPh=1-phenylpyrazole). The solution chemistry of these compounds, under physiological-like conditions, was investigated through UV–vis absorption and 1H NMR spectroscopies. Significant cytotoxic effects in vitro were observed in selected cases.