Acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia accompanying ARID1B gene mutation

In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow sampl...

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Published inHematology (Luxembourg) Vol. 28; no. 1; p. 2227495
Main Authors Wu, Danyang, Gao, Ran
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.12.2023
Subjects
acute myeloid leukemia
acute promyelocytic leukemia
NUP98::RARG
Translocation(11;12)(p15;q13)
NUP98::RARG
Translocation(11;12)(p15;q13)
acute promyelocytic leukemia
acute myeloid leukemia
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Abstract In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow samples revealed the presence of the NUP98-retinoic acid receptor gamma (RARG) (NUP98::RARG) gene resulting from the translocation. Furthermore, the presence of a mutation in the ARID1B gene in the patient under study indicates a potential association with resistance to all-trans retinoic acid (ATRA).
AbstractList In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow samples revealed the presence of the NUP98-retinoic acid receptor gamma (RARG) (NUP98::RARG) gene resulting from the translocation. Furthermore, the presence of a mutation in the ARID1B gene in the patient under study indicates a potential association with resistance to all-trans retinoic acid (ATRA).
ABSTRACTIn this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow samples revealed the presence of the NUP98-retinoic acid receptor gamma (RARG) (NUP98::RARG) gene resulting from the translocation. Furthermore, the presence of a mutation in the ARID1B gene in the patient under study indicates a potential association with resistance to all-trans retinoic acid (ATRA).
In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow samples revealed the presence of the NUP98-retinoic acid receptor gamma (RARG) (NUP98::RARG) gene resulting from the translocation. Furthermore, the presence of a mutation in the ARID1B gene in the patient under study indicates a potential association with resistance to all-trans retinoic acid (ATRA).In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow samples revealed the presence of the NUP98-retinoic acid receptor gamma (RARG) (NUP98::RARG) gene resulting from the translocation. Furthermore, the presence of a mutation in the ARID1B gene in the patient under study indicates a potential association with resistance to all-trans retinoic acid (ATRA).
Author Wu, Danyang
Gao, Ran
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Cites_doi 10.1016/j.leukres.2018.12.009
10.1002/ajh.25689
10.1038/s41375-018-0338-z
10.1056/NEJMoa1300874
10.1038/s41416-019-0456-z
10.1007/s00277-014-2073-5
10.2147/OTT.S273172
10.1097/MPH.0000000000002331
10.1182/blood-2017-11-818716
10.4274/tjh.galenos.2022.2022.0475
10.3390/cancers12040967
10.1182/bloodadvances.2019000404
10.1186/s40364-021-00284-x
10.1158/0008-5472.CAN-18-0840
10.1097/MD.0000000000022488
10.1182/blood-2010-06-291658
10.1038/leu.2016.69
10.1182/bloodadvances.2017014183
10.3324/haematol.2019.244715
10.1182/bloodadvances.2022008364
10.1038/leu.2017.167
10.1038/leu.2014.334
10.3760/cma.j.cn112137-20201103-03005
10.1096/fasebj.10.9.8801176
10.1177/2040620720976984
10.1111/bjh.18144
10.1080/10428194.2018.1553302
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Translocation(11;12)(p15;q13)
acute promyelocytic leukemia
acute myeloid leukemia
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Snippet In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and...
ABSTRACTIn this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical,...
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SubjectTerms acute myeloid leukemia
acute promyelocytic leukemia
NUP98::RARG
Translocation(11;12)(p15;q13)
Title Acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia accompanying ARID1B gene mutation
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