Acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia accompanying ARID1B gene mutation

In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow sampl...

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Bibliographic Details
Published inHematology (Luxembourg) Vol. 28; no. 1; p. 2227495
Main Authors Wu, Danyang, Gao, Ran
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.12.2023
Subjects
acute myeloid leukemia
acute promyelocytic leukemia
NUP98::RARG
Translocation(11;12)(p15;q13)
NUP98::RARG
Translocation(11;12)(p15;q13)
acute promyelocytic leukemia
acute myeloid leukemia
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Summary:In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow samples revealed the presence of the NUP98-retinoic acid receptor gamma (RARG) (NUP98::RARG) gene resulting from the translocation. Furthermore, the presence of a mutation in the ARID1B gene in the patient under study indicates a potential association with resistance to all-trans retinoic acid (ATRA).
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ISSN:1607-8454
1607-8454
DOI:10.1080/16078454.2023.2227495