Minimization of apoptosis-inducing CPP-Bim peptide

[Display omitted] Pro-apoptotic peptides may be promising agents for cancer therapy owing to their ability to induce apoptosis in cancer cells. TatBim, a fusion peptide of Tat cell-penetrating peptide (CPP) and the BH3 domain derived from Bim apoptosis-inducing protein, is a pro-apoptotic peptide. I...

Full description

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 36; p. 127811
Main Authors Zhou, Shengli, Watanabe, Kazunori, Koide, Seiichiro, Kitamatsu, Mizuki, Ohtsuki, Takashi
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.03.2021
Subjects
Apoptosis
Bim
Cell penetrating peptide
Poly(Arg)
Tat
Cell penetrating peptide
Poly(Arg)
Tat
Bim
Apoptosis
Online AccessGet full text

Cover

More Information
Summary:[Display omitted] Pro-apoptotic peptides may be promising agents for cancer therapy owing to their ability to induce apoptosis in cancer cells. TatBim, a fusion peptide of Tat cell-penetrating peptide (CPP) and the BH3 domain derived from Bim apoptosis-inducing protein, is a pro-apoptotic peptide. In this study, based on the TatBim sequence, we attempted to minimize the CPP-Bim peptide while retaining apoptosis-inducing activity. The CPP and Bim parts were systematically shortened, and the pro-apoptotic activities of the shortened peptides were examined. We obtained TatBim-N1C2 and R8Bim-N1C2 as minimized peptides with efficient apoptotic activity. These peptides may have potential applications in future biomedical studies, such as cancer therapeutics.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2021.127811