A possible role of GLP-1 in the pathophysiology of early dumping syndrome

• Published in: Digestive diseases and sciences Vol. 50; no. 12; pp. 2263 - 2267
• Main Authors: YAMAMOTO, Hiroshi, MORI, Tsuyoshi, TSUCHIHASHI, Hiroshi, AKABORI, Hiroya, NAITO, Hiroyuki, TANI, Tohru
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.12.2005; Springer Nature B.V
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Biomarkers - blood; Blood Glucose - analysis; Case-Control Studies; Catecholamines - blood; Dumping Syndrome - blood; Dumping Syndrome - diagnosis; Dumping Syndrome - etiology; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastrectomy - adverse effects; Gastrectomy - methods; Gastroenterology. Liver. Pancreas. Abdomen; Glucagon-Like Peptide 1 - blood; Hemodynamics - physiology; Humans; Insulin - blood; Linear Models; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Prognosis; Reference Values; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Vertebrates: anatomy and physiology, studies on body, several organs or systems; GLP-1; Pathophysiology; sympathetic; Gastroenterology; Digestive diseases; Metabolic diseases; Dumping syndrome; Norepinephrine; Catecholamine; Insulin; Gastric disease
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-005-3046-2

Exaggerated plasma concentrations of GLP-1 precede reactive hypoglycemia after oral glucose in gastrectomy patients, resulting in late dumping syndrome. Recently, we showed that GLP-1 elicits the activation of sympathetic outflow. Because sympathetic activation is thought to be a cause of early dumping, we hypothesized that exaggerated GLP-1 may contribute to the pathophysiology of early dumping syndrome. In 11 patients after gastrectomy and 14 controls, blood pressure, heart rate, and plasma concentrations of norepinephrine, epinephrine, GLP-1, glucagon, insulin, and glucose were measured after oral glucose. In gastrectomy patients, GLP-1, norepinephrine, and heart rate peaked 15 to 30 min after oral glucose. Significant positive correlations were found among GLP-1, norepinephrine, and heart rate at 30 min, and these parameters at 30 min were significantly higher in patients with early dumping syndrome. These results suggest that GLP-1 is involved in the pathophysiology of early dumping syndrome.