Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study

[Display omitted] This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-perfor...

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Published inRevista brasileira de farmacognosia Vol. 29; no. 6; pp. 744 - 748
Main Authors Lv, Tong- tong, Ju, Cheng-guo, Liu, Bo-nan, Ren, Xiao-hang, Shan, Guo-shun, Jia, Tian-zhu
Format Journal Article
LanguageEnglish
Published Cham Elsevier Editora Ltda 01.11.2019
Springer International Publishing
Sociedade Brasileira de Farmacognosia
Subjects
Excretion
Original Article
PHARMACOLOGY & PHARMACY
Pharmacy
Plasma concentration
Tissue distribution
Wine-processing technology
Excretion
Tissue distribution
Wine-processing technology
Plasma concentration
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Summary:[Display omitted] This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism.
ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1016/j.bjp.2019.08.005