Skin autofluorescence and cause-specific mortality in a population-based cohort

• Published in: Scientific reports Vol. 14; no. 1; pp. 19967 - 9
• Main Authors: Boersma, Henderikus E., Smit, Andries J., Paterson, Andrew D., Wolffenbuttel, Bruce H. R., van der Klauw, Melanie M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/53/2423; 692/420/256/2515; 692/699/67/2324; Adult; Advanced glycation end-products; Aged; Cancer; Cardiovascular diseases; Cardiovascular Diseases - mortality; Cause of Death; Cohort Studies; Diabetes mellitus; Female; Humanities and Social Sciences; Humans; Male; Middle Aged; Mortality; multidisciplinary; Neoplasms - mortality; Optical Imaging; Prediction; Proportional Hazards Models; Regression analysis; Risk Factors; Science; Science (multidisciplinary); Skin - pathology; Skin autofluorescence; Skin diseases; Smoking; Skin autofluorescence; Advanced glycation end-products; Mortality; Prediction
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-71037-7

We aimed to assess the association of SAF with cardiovascular mortality in the general population and the possible association between SAF with other disease-specific mortality rates. We evaluated 77,143 participants without known diabetes or cardiovascular disease. The cause of death was ascertained by the municipality database. The associations between SAF and all-cause mortality, cardiovascular mortality and cancer mortality were assessed with Cox proportional hazard analysis.After a median follow-up of 115 months, 1447 participants were deceased (1.9%). SAF and age-adjusted SAF-z score were higher in all mortality groups. Cox regression analysis revealed that the highest quartile of SAF was associated with increased odds of cardiovascular mortality, (HR) 12.6 (7.3–21.7) and after adjusting for age (HR 1.8 (1.0–3.2)). Significance was lost after additional adjustments for sex, smoking status, and BMI (HR 1.4 (0.8–2.5). For cancer-related mortality the highest quartile of SAF was associated with higher probability of mortality in all models (unadjusted HR 8.6 (6.6–11.3), adjusted for age HR 2.1 (1.6–2.8)), adjusted for age, sex, smoking status, and BMI HR 1.7 (1.3–2.4)). SAF is associated with all-cause mortality as well as cardiovascular and cancer-related mortality in the general population.