Central nervous system metastasis from osteosarcoma: Case report and literature review

Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn’t have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Ce...

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Published inReports of practical oncology and radiotherapy Vol. 23; no. 4; pp. 266 - 269
Main Authors Nieto-Coronel, María Tereza, López-Vásquez, Allan David, Marroquín-Flores, Diana, Ruiz-Cruz, Sandy, Martínez-Tláhuel, Jorge Luis, De la Garza-Salazar, Jaime
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Sp. z o.o 01.07.2018
Elsevier
Subjects
Brain metastasis
Case report
Osteosarcoma
Radiation therapy
Osteosarcoma
Brain metastasis
Radiation therapy
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Summary:Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn’t have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2–6.5%, increase to 10–15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as recursive partitioning analysis (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died.
ISSN:1507-1367
2083-4640
DOI:10.1016/j.rpor.2018.06.003